Western Blot (WB)
(Western Blot: Sample: Lane1: Human K562 Cells; Lane2: Porcine Brain Tissue; Lane3: Porcine Kidney Tissue.)
Rabbit anti-Human FK506 Binding Protein 4 Polyclonal Antibody | anti-FKBP4 antibody
Polyclonal Antibody to FK506 Binding Protein 4 (FKBP4)
Immunocytochemistry in formalin fixed cells: 5-20ug/mL
Immunohistochemistry in formalin fixed frozen section: 5-20ug/mL
Immunohistochemistry in paraffin section: 5-20ug/mL
Enzyme-linked Immunosorbent Assay: 0.05-2ug/mL
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Lane1: Human K562 Cells; Lane2: Porcine Brain Tissue; Lane3: Porcine Kidney Tissue.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Human K562 Cells; Lane2: Porcine Brain Tissue; Lane3: Porcine Kidney Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant FKBP4, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant FKBP4, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Human Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Human Tissue))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
Uniprot Description
FKBP4: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.
Protein type: Chaperone; EC 5.2.1.8; Isomerase
Chromosomal Location of Human Ortholog: 12p13.33
Cellular Component: axonal growth cone; cell soma; cytoplasm; cytosol; extracellular exosome; microtubule; mitochondrion; nucleoplasm; perinuclear region of cytoplasm; protein complex
Molecular Function: ATP binding; copper-dependent protein binding; FK506 binding; glucocorticoid receptor binding; GTP binding; heat shock protein binding; peptidyl-prolyl cis-trans isomerase activity; phosphoprotein binding; protein binding; protein binding, bridging; RNA binding; tau protein binding
Biological Process: androgen receptor signaling pathway; copper ion transport; embryo implantation; male sex differentiation; negative regulation of microtubule polymerization; negative regulation of microtubule polymerization or depolymerization; negative regulation of neuron projection development; prostate gland development; protein complex localization; protein folding; protein peptidyl-prolyl isomerization; regulation of cellular response to heat; steroid hormone receptor complex assembly
Research Articles on FKBP4
Similar Products
Product Notes
The FKBP4 fkbp4 (Catalog #AAA2027324) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to FK506 Binding Protein 4 (FKBP4) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FK506 Binding Protein 4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 1-5ug/mL Immunocytochemistry in formalin fixed cells: 5-20ug/mL Immunohistochemistry in formalin fixed frozen section: 5-20ug/mL Immunohistochemistry in paraffin section: 5-20ug/mL Enzyme-linked Immunosorbent Assay: 0.05-2ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the FKBP4 fkbp4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FK506 Binding Protein 4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
