Western Blot (WB)
(Western Blot Analysis: Representative lot data. Mouse brain lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-FRS3 (1:2,000) dilution of this lot). Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates protein FRS3 (~54kD). )
Rabbit Fibroblast Growth Factor Receptor Substrate 3 Polyclonal Antibody | anti-FRS3 antibody
Fibroblast Growth Factor Receptor Substrate 3 (FRS3, FGFR Substrate 3, FGFR-signaling adaptor SNT2, Suc1-associated Neurotrophic Factor Target 2, SNT-2) (Biotin)
Gene Names
Frs3; Snt2; AI449674; Frs2beta; 4930417B13Rik
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
Purified by affinity chromatography.
Synonyms
Fibroblast Growth Factor Receptor Substrate 3; Polyclonal Antibody; Fibroblast Growth Factor Receptor Substrate 3 (FRS3; FGFR Substrate 3; FGFR-signaling adaptor SNT2; Suc1-associated Neurotrophic Factor Target 2; SNT-2) (Biotin); anti-FRS3 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human FRS3/FRS2b. Species crossreactivity: mouse, rat.
Purity/Purification
Purified by affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Applicable Applications for anti-FRS3 antibody
Western Blot (WB)
Application Notes
WB: 1:2000
Applications are based on unconjugated antibody.
Applications are based on unconjugated antibody.
Immunogen
Linear peptide corresponding to aa 361-375 of FRS3/ FRS2b (KLH). Cellular Localization: Membrane; Lipid-anchor. Epitope: PTB.
Conjugate
Biotin
Positive Control
Mouse brain tissue lysate
Note
Preservative Free
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Western Blot (WB)
(Western Blot Analysis: Representative lot data. Mouse brain lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-FRS3 (1:2,000) dilution of this lot). Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates protein FRS3 (~54kD). )
Western Blot (WB)
(Western Blot Analysis: Representative lot data. Mouse brain lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-FRS3 (1:2,000) dilution of this lot). Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates protein FRS3 (~54kD). )
Product Categories/Family for anti-FRS3 antibody
References
1. Huang, L., et al. (2006). Oncogene 24(49): 6457-6466.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
54kDa
NCBI Official Full Name
fibroblast growth factor receptor substrate 3
NCBI Official Synonym Full Names
fibroblast growth factor receptor substrate 3
NCBI Official Symbol
Frs3
NCBI Official Synonym Symbols
Snt2; AI449674; Frs2beta; 4930417B13Rik
NCBI Protein Information
fibroblast growth factor receptor substrate 3
UniProt Protein Name
Fibroblast growth factor receptor substrate 3
Protein Family
UniProt Gene Name
FRS3
UniProt Synonym Gene Names
FGFR substrate 3; SNT-2
UniProt Entry Name
FRS3_HUMAN
Uniprot Description
FRS3: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: plasma membrane
Molecular Function: protein binding; insulin receptor binding; fibroblast growth factor receptor binding
Biological Process: fibroblast growth factor receptor signaling pathway; signal transduction
Research Articles on FRS3
Similar Products
Product Notes
The FRS3 frs3 (Catalog #AAA6476976) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Fibroblast Growth Factor Receptor Substrate 3 (FRS3, FGFR Substrate 3, FGFR-signaling adaptor SNT2, Suc1-associated Neurotrophic Factor Target 2, SNT-2) (Biotin) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Fibroblast Growth Factor Receptor Substrate 3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:2000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the FRS3 frs3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Fibroblast Growth Factor Receptor Substrate 3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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