Goat anti-Human Fibrinogen Polyclonal Antibody | anti-FGG antibody

Goat Polyclonal to Human Fibrinogen

Cat. Num. AAA242249

• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Delipidated and defibrinated
• Synonyms: Fibrinogen; Polyclonal Antibody; Goat Polyclonal to Human Fibrinogen; Anti-Fibrinogen Antibody IHC-plus; Human Fibrinogen; anti-FGG antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Fibrinogen [Human Plasma].
• Purity/Purification: Delipidated and defibrinated
• Form/Format: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide
• Concentration: 90 mg/ml (varies by lot)
• Sequence Length: 444

• Applicable Applications for anti-FGG antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, IHC-P (1:500), WB; Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Target Species: Human
• Immunogen Description: Purified fibrinogen from human plasma.
• Usage Summary: Immunohistochemistry: MBS242249 was validated for use in immunohistrochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retiecal in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinyated secondary antibody , followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specific. The optimal working concentration for MBS242249 was determined to be 1:500
• Immunogen: Fibrinogen antibody was raised against purified fibrinogen from human plasma.
• Preparation and Storage: +4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-Fibrinogen antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.)

NCBI and Uniprot Product Information

• NCBI GI #: 350
• NCBI GeneID: 280792
• UniProt Accession #: P12799
• Molecular Weight: 50,244 Da
• NCBI Official Full Name: fibrinogen
• NCBI Official Synonym Full Names: fibrinogen gamma chain
• NCBI Official Symbol: FGG
• NCBI Protein Information: fibrinogen gamma-B chain; gamma'; fibrinogen, gamma polypeptide
• UniProt Protein Name: Fibrinogen gamma-B chain
• Protein Family: Fibrinogen
• UniProt Gene Name: FGG
• UniProt Synonym Gene Names: Gamma'
• UniProt Entry Name: FIBG_BOVIN

Uniprot Description

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.