Rabbit anti-Human, Mouse Fgfr1 Polyclonal Antibody | anti-Fgfr1 antibody

Fgfr1, CT (Fgfr1, Flg, Fibroblast growth factor receptor 1, Basic fibroblast growth factor receptor 1, MFR, Proto-oncogene c-Fgr, CD331) (Biotin)

Cat. Num. AAA6299123

• Gene Names: Fgfr1; FLG; Fr1; MFR; Eask; Hspy; Flt-2; c-fgr; FGFR-I; Fgfr-1; AW208770; bFGF-R-1
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Fgfr1; Polyclonal Antibody; CT (Fgfr1; Flg; Fibroblast growth factor receptor 1; Basic fibroblast growth factor receptor 1; MFR; Proto-oncogene c-Fgr; CD331) (Biotin); CD331; anti-Fgfr1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Sequence Length: 733

• Applicable Applications for anti-Fgfr1 antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: IHC: 1:10-50; ELISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: Mouse Fgfr1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 755-784 amino acids from the C-terminal region of Mouse Fgfr1.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Mouse Fgfr1 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the Fgfr1 antibody detected the Fgfr1 protein (arrow).)

Immunohistochemistry (IHC)

(Mouse Fgfr1 Antibody (C-term) (AP14840b)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse adrenal glands followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Fgfr1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-Fgfr1 antibody

Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF). Receptor for FGF23 in the presence of KL.

Product Categories/Family for anti-Fgfr1 antibody

Antibodies; CD Markers

References

Drogat, B., et al. Blood 116(12):2141-2151(2010). Bowles, J., et al. Dev. Cell 19(3):440-449(2010). Chung, W.C., et al. J. Neuroendocrinol. 22(8):944-950(2010). Pond, A.C., et al. Cancer Res. 70(12):4868-4879(2010). Maruyama, T., et al. Sci Signal 3 (123), RA40 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 120952633
• NCBI GeneID: 14182
• NCBI Accession #: NP_001073378.1; NP_001073377.1
• NCBI GenBank Nucleotide #: NP_001073378.1
• UniProt Accession #: P16092
• NCBI Official Full Name: fibroblast growth factor receptor 1 isoform 3
• NCBI Official Synonym Full Names: fibroblast growth factor receptor 1
• NCBI Official Symbol: Fgfr1
• NCBI Official Synonym Symbols: FLG; Fr1; MFR; Eask; Hspy; Flt-2; c-fgr; FGFR-I; Fgfr-1; AW208770; bFGF-R-1
• NCBI Protein Information: fibroblast growth factor receptor 1
• UniProt Protein Name: Fibroblast growth factor receptor 1
• Protein Family: FGFR1 oncogene partner
• UniProt Gene Name: Fgfr1
• UniProt Synonym Gene Names: Flg; FGFR-1; bFGF-R-1
• UniProt Entry Name: FGFR1_MOUSE

Uniprot Description

FGFR1: a receptor tyrosine kinase of the highly-conserved fibroblast growth factor receptor (FGFR). Binds both acidic and basic fibroblast growth factors and is involved in limb induction. Point mutations cause Pfeffer syndrome (finger and toe malformations and other skeletal errors) and dominant Kallmann syndrome 2. Stem cell leukemia lymphoma syndrome (SCLL) may be caused by a t(8;13)(p12;q12) translocation that fuses a zinc finger gene, ZNF198, to FGFR1. Various myeloproliferative disorders have been linked to translocations that fuse FGFR1 to FOP, FIM, CEP1 or the atypical kinase, Bcr. Inhibitor: SU5402. 20 isoforms of the human protein produced by alternative splicing have been described.

Protein type: Membrane protein, integral; Oncoprotein; Protein kinase, tyrosine (receptor); Kinase, protein; Protein kinase, TK; EC 2.7.10.1; TK group; FGFR family

Cellular Component: cytoplasm; cytoplasmic vesicle; integral to membrane; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; receptor complex

Molecular Function: ATP binding; cell adhesion molecule binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; glycoprotein binding; heparin binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein complex binding; protein homodimerization activity; protein kinase activity; protein-tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: angiogenesis; auditory receptor cell development; blood vessel morphogenesis; brain development; cell maturation; central nervous system neuron development; chondrocyte differentiation; embryonic limb morphogenesis; fibroblast growth factor receptor signaling pathway; generation of neurons; in utero embryonic development; induction of an organ; inner ear morphogenesis; lung development; mesenchymal cell differentiation; midbrain development; middle ear morphogenesis; motogenic signaling involved in postnatal olfactory bulb interneuron migration; negative regulation of osteoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; neurite development; neuroblast division in the ventricular zone; orbitofrontal cortex development; outer ear morphogenesis; paraxial mesoderm development; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; regulation of gene expression; regulation of lateral mesodermal cell fate specification; regulation of phosphorus metabolic process; regulation of sensory perception of pain; salivary gland morphogenesis; sensory perception of sound; stem cell maintenance; ureteric bud development; vacuolar phosphate transport