Western Blot (WB)
(Anti- FGF2 Picoband antibody, MBS178087, Western blottingAll lanes: Anti FGF2 (MBS178087) at 0.5ug/mlLane 1: Human Placenta Tissue Lysate at 50ugLane 2: Rat Brain Tissue Lysate at 50ugLane 3: Rat Kidney Tissue Lysate at 50ugLane 4: Rat Spleen Tissue Lysate at 50ugPredicted bind size: 17KDObserved bind size: 17KD)
anti-Human, Rat FGF2 Polyclonal Antibody | anti-FGF2 antibody
Anti-FGF2 Antibody
Western Blot (WB)
(Anti- FGF2 Picoband antibody, MBS178087, Western blottingAll lanes: Anti FGF2 (MBS178087) at 0.5ug/mlLane 1: Human Placenta Tissue Lysate at 50ugLane 2: Rat Brain Tissue Lysate at 50ugLane 3: Rat Kidney Tissue Lysate at 50ugLane 4: Rat Spleen Tissue Lysate at 50ugPredicted bind size: 17KDObserved bind size: 17KD)
Western Blot (WB)
(Anti- FGF2 Picoband antibody, MBS178087, Western blottingAll lanes: Anti FGF2 (MBS178087) at 0.5ug/mlLane 1: Human Placenta Tissue Lysate at 50ugLane 2: Rat Brain Tissue Lysate at 50ugLane 3: Rat Kidney Tissue Lysate at 50ugLane 4: Rat Spleen Tissue Lysate at 50ugPredicted bind size: 17KDObserved bind size: 17KD)
Background: FGF2 has been implicated in a multitude of physiologic and pathologic processes, including limb development, angiogenesis, wound healing, and tumor growth. Human FGF2 shares 96% and 97% amino acid sequence homology with mouse and rat respectively. FGF2 belongs to the fibroblast growth factor (FGF) family. Fibroblast growth factors (FGFs) exhibit widespread mitogenic and neurotrophic activities. Nine members of the family are currently known, and FGF-1 and FGF-2 are present in relatively high levels in CNS. FGF-2 is expressed by at low levels in many tissues and cell types and reaches high concentrations in brain and pituitary.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
Uniprot Description
FGF2: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative initiation.
Protein type: Motility/polarity/chemotaxis; Activator
Chromosomal Location of Human Ortholog: 4q26
Cellular Component: extracellular region; extracellular space; nucleus
Molecular Function: 1-phosphatidylinositol-3-kinase activity; chemoattractant activity; cytokine activity; fibroblast growth factor receptor binding; growth factor activity; heparin binding; ligand-dependent nuclear receptor transcription coactivator activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: activation of MAPK activity; cell migration during sprouting angiogenesis; chemotaxis; embryonic morphogenesis; extracellular matrix organization and biogenesis; fibroblast growth factor receptor signaling pathway; growth factor dependent regulation of satellite cell proliferation; hyaluronan catabolic process; inositol phosphate biosynthetic process; MAPKKK cascade; negative regulation of blood vessel endothelial cell migration; nervous system development; organ morphogenesis; peptidyl-tyrosine phosphorylation; phosphatidylinositol biosynthetic process; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; positive chemotaxis; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cardiac muscle cell proliferation; positive regulation of cell division; positive regulation of cell fate specification; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of MAP kinase activity; positive regulation of phosphoinositide 3-kinase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; Ras protein signal transduction; regulation of angiogenesis; regulation of phosphoinositide 3-kinase cascade; release of sequestered calcium ion into cytosol; signal transduction; somatic stem cell maintenance; ureteric bud branching; wound healing
Research Articles on FGF2
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Product Notes
The FGF2 fgf2 (Catalog #AAA178087) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-FGF2 Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's FGF2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the FGF2 fgf2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FGF2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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