Rabbit anti-Human, mouse FFAR3 Polyclonal Antibody | anti-FFAR3 antibody

FFAR3 Antibody; Biotin conjugated

Cat. Num. AAA7002917

• Gene Names: FFAR3; FFA3R; GPR41; GPR42
• Reactivity: Human, mouse
• Applications: ELISA
• Purity: >95%,Protein G purified
• Synonyms: FFAR3; Polyclonal Antibody; FFAR3 Antibody; Biotin conjugated; Free fatty acid receptor 3; G-protein coupled receptor 41; GPR41; anti-FFAR3 antibody

• Host: Rabbit
• Reactivity: Human, mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 346

• Applicable Applications for anti-FFAR3 antibody: ELISA (EIA)
• Immunogen: Recombinant human Free fatty acid receptor 3 protein
• Conjugation: Biotin
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-131161 / sc-131163 / sc-131166 / sc-98332
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Related Product Information for anti-FFAR3 antibody

G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator (PubMed:12496283, PubMed:12711604).

NCBI and Uniprot Product Information

• NCBI GI #: 4885329
• NCBI GeneID: 2865
• NCBI Accession #: NP_005295.1
• NCBI GenBank Nucleotide #: NM_005304.3
• UniProt Accession #: O14843; Q14CM7; B2RWM8
• Molecular Weight: 38,649 Da
• NCBI Official Full Name: free fatty acid receptor 3
• NCBI Official Synonym Full Names: free fatty acid receptor 3
• NCBI Official Symbol: FFAR3
• NCBI Official Synonym Symbols: FFA3R; GPR41; GPR42
• NCBI Protein Information: free fatty acid receptor 3
• UniProt Protein Name: Free fatty acid receptor 3
• Protein Family: Free fatty acid receptor
• UniProt Gene Name: FFAR3
• UniProt Synonym Gene Names: GPR41
• UniProt Entry Name: FFAR3_HUMAN

Uniprot Description

FFAR3: Receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1,4,5- trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation. Coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein. The rank order of potency for agonists of this receptor is propionate = pentanoate = butyrate > acetate > formate. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; lipid binding

Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; inflammatory response; mucosal immune response; negative regulation of blood pressure; positive regulation of acute inflammatory response to non-antigenic stimulus; positive regulation of chemokine production; positive regulation of cytokine production during immune response; regulation of hormone biosynthetic process; regulation of norepinephrine secretion