Rabbit anti-Human FER Polyclonal Antibody | anti-FER antibody

FER, CT (Tyrosine-protein Kinase Fer, Proto-oncogene c-Fer, p94-FER, Tyrosine Kinase 3, TYK3) (MaxLight 750)

Cat. Num. AAA6475829

• Gene Names: FER; FerT; TYK3; PPP1R74
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein G Affinity Chromatography.
• Synonyms: FER; Polyclonal Antibody; CT (Tyrosine-protein Kinase Fer; Proto-oncogene c-Fer; p94-FER; Tyrosine Kinase 3; TYK3) (MaxLight 750); anti-FER antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FER.
• Purity/Purification: Purified by Protein G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

• Applicable Applications for anti-FER antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-1:500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the C-terminal region of human FER (KLH).
• Conjugate: MaxLight750
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-FER antibody

Antibodies; Tyrosine Kinases

References

1. Greer, P., Nat. Rev. Mol. Cell Biol. 3(4):278-289 (2002). 2. Rosato, R., et al., Mol. Cell. Biol. 18(10):5762-5770 (1998). 3. Kim, L., et al., J. Biol. Chem. 273(36):23542-23548 (1998). 4. Warrington, J.A., et al., Genomics 11(3):701-708 (1991). 5. Morris, C., et al., Cytogenet. Cell Genet. 53(4):196-200 (1990).

NCBI and Uniprot Product Information

• NCBI GI #: 119964721
• NCBI GeneID: 2241
• NCBI Accession #: NP_005237.2
• NCBI GenBank Nucleotide #: NM_005246.2
• UniProt Accession #: P16591; B2RCR4; B4DSQ2; H2FLB8
• Molecular Weight: 85kDa
• NCBI Official Full Name: tyrosine-protein kinase Fer
• NCBI Official Synonym Full Names: fer (fps/fes related) tyrosine kinase
• NCBI Official Symbol: FER
• NCBI Official Synonym Symbols: FerT; TYK3; PPP1R74
• NCBI Protein Information: tyrosine-protein kinase Fer; p94-Fer; tyrosine kinase 3; phosphoprotein NCP94; proto-oncogene c-Fer; feline encephalitis virus-related kinase FER; protein phosphatase 1, regulatory subunit 74; fujinami poultry sarcoma/Feline sarcoma-related protein Fer
• UniProt Protein Name: Tyrosine-protein kinase Fer
• Protein Family: Ferritin
• UniProt Gene Name: FER
• UniProt Synonym Gene Names: TYK3
• UniProt Entry Name: FER_HUMAN

NCBI Description

Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq, Jul 2008]

Uniprot Description

Fer: a non-receptor tyrosine kinase of the Fer family. Regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Increased expression associated with prostate cancer proliferation, and antisense blocks soft agar growth.

Protein type: Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Oncoprotein; EC 2.7.10.2; TK group; Fer family

Chromosomal Location of Human Ortholog: 5q21

Cellular Component: microtubule cytoskeleton; extrinsic to internal side of plasma membrane; lamellipodium; cytoplasm; nuclear chromatin; cell cortex; cytosol; nucleus; cell junction; actin cytoskeleton

Molecular Function: protein binding; cadherin binding; gamma-catenin binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; actin binding; lipid binding; protein kinase binding; protein phosphatase 1 binding; Rab GTPase binding; ATP binding; epidermal growth factor receptor binding

Biological Process: regulation of mast cell degranulation; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; diapedesis; tyrosine phosphorylation of Stat3 protein; response to lipopolysaccharide; platelet-derived growth factor receptor signaling pathway; negative regulation of mast cell activation during immune response; chemotaxis; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; positive regulation of cell proliferation; cell adhesion; cell differentiation; regulation of protein amino acid phosphorylation; cytokine and chemokine mediated signaling pathway; microtubule cytoskeleton organization and biogenesis; regulation of epidermal growth factor receptor signaling pathway; regulation of cell proliferation; cell proliferation; positive regulation of actin filament polymerization; cellular response to insulin stimulus; actin cytoskeleton reorganization; innate immune response; mitotic cell cycle; positive regulation of cell migration