Rabbit anti-Human, Mouse FCGR2C Polyclonal Antibody | anti-FCGR2C antibody

FCGR2C, CT (CD32, CDw32, Fc-gamma RII-c, Fc-gamma-RIIc, FcRII-c, Low Affinity Immunoglobulin gamma Fc Region Receptor II-c, IgG Fc Receptor II-c, CD32, FCG2, IGFR2) (MaxLight 405)

Cat. Num. AAA6475759

• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FCGR2C; Polyclonal Antibody; CT (CD32; CDw32; Fc-gamma RII-c; Fc-gamma-RIIc; FcRII-c; Low Affinity Immunoglobulin gamma Fc Region Receptor II-c; IgG Fc Receptor II-c; CD32; FCG2; IGFR2) (MaxLight 405); anti-FCGR2C antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FCGR2C. Species Crossreactivity: mouse
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

• Applicable Applications for anti-FCGR2C antibody: Western Blot (WB), FLISA, Immunohistochemistry (IHC)
• Application Notes: WB: 1:100-1:500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 281-307 in the C-terminal region of human FCGR2C, UniProt Accession #NP_001005410.2; P31995; P12318.
• Conjugate: MaxLight405
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in mouse brain tissue lysates (35ug/lane) usingMBS631339. FCGR2C (arrow) was detected usingF0025-92.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human lung carcinoma usingMBS631339, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of MBS631339 for immunohistochemistry.)

Product Categories/Family for anti-FCGR2C antibody

Antibodies; Receptors

References

1. Metes D., et.al., Blood 91:2369-2380(1998). 2. Stuart S.G., et.al., EMBO J. 8:3657-3666(1989).

NCBI and Uniprot Product Information

• NCBI GI #: 126116583
• UniProt Accession #: P31995; P12318
• Molecular Weight: 35.578
• UniProt Protein Name: Low affinity immunoglobulin gamma Fc region receptor II-c
• Protein Family: Low affinity immunoglobulin gamma Fc region receptor
• UniProt Gene Name: FCGR2C
• UniProt Synonym Gene Names: CD32; FCG2; IGFR2; IgG Fc receptor II-c; Fc-gamma-RIIc; FcRII-c
• UniProt Entry Name: FCG2C_HUMAN

Uniprot Description

FCGR2C: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: cytoplasm; plasma membrane; integral to membrane

Molecular Function: protein binding; transmembrane receptor activity; IgG binding

Biological Process: immune response; signal transduction

Disease: Thrombocytopenic Purpura, Autoimmune