Rabbit anti-Human FCGR2B Polyclonal Antibody | anti-FCGR2B antibody

FCGR2B, CT (FCGR2B, CD32, FCG2, IGFR2, Low affinity immunoglobulin gamma Fc region receptor II-b, CDw32, Fc-gamma RII-b, CD32) (Azide free) (HRP)

Cat. Num. AAA6298641

• Gene Names: FCGR2B; CD32; FCG2; CD32B; FCGR2; IGFR2
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: FCGR2B; Polyclonal Antibody; CT (FCGR2B; CD32; FCG2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-b; CDw32; Fc-gamma RII-b; CD32) (Azide free) (HRP); anti-FCGR2B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FCGR2B.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-FCGR2B antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 250-279 in the C-terminal region of human FCGR2B, UniProt Accession #P31994; NP_003992.3; NP_001002273.1; NP_001177757.1; NP_001002274.1
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in HL-60 cell line lysates (35ug/lane) usingMBS6007452. This demonstrates that MBS6007452 detected the FCGR2B protein (arrow).)

Related Product Information for anti-FCGR2B antibody

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-FCGR2B antibody

Antibodies; CD Markers

References

1. Prokopec, K.E., et al. Clin. Immunol. 137(3):322-329(2010). 2. Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010). 3. Zhang, C.Y., et al. J. Biol. Chem. 285(44):34250-34258(2010). 4. Niederer, H.A., et al. Hum. Mol. Genet. 19(16):3282-3294(2010). 5. Guilabert, A., et al. J. Am. Acad. Dermatol. 63(1):161-163(2010).

NCBI and Uniprot Product Information

• NCBI GI #: 50511930
• NCBI GeneID: 2213
• NCBI Accession #: NP_003992.3; NP_001002273.1; NP_001177757.1; NP_001002274.1
• NCBI GenBank Nucleotide #: NM_004001.4
• UniProt Accession #: P31994; O95649; Q53X85; Q5VXA9; Q8NIA1; A6H8N3
• Molecular Weight: 33,450 Da
• NCBI Official Full Name: low affinity immunoglobulin gamma Fc region receptor II-b isoform 1
• NCBI Official Synonym Full Names: Fc fragment of IgG, low affinity IIb, receptor (CD32)
• NCBI Official Symbol: FCGR2B
• NCBI Official Synonym Symbols: CD32; FCG2; CD32B; FCGR2; IGFR2
• NCBI Protein Information: low affinity immunoglobulin gamma Fc region receptor II-b; CDw32; fcRII-b; Fc gamma RIIb; fc-gamma-RIIb; fc-gamma RII-b; igG Fc receptor II-b; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD
• UniProt Protein Name: Low affinity immunoglobulin gamma Fc region receptor II-b
• Protein Family: Low affinity immunoglobulin gamma Fc region receptor
• UniProt Gene Name: FCGR2B
• UniProt Synonym Gene Names: CD32; FCG2; IGFR2; IgG Fc receptor II-b; Fc-gamma-RIIb; FcRII-b
• UniProt Entry Name: FCG2B_HUMAN

NCBI Description

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Uniprot Description

FCGR2B: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed.

Protein type: Membrane protein, integral; Cell surface; Oncoprotein

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding; IgG binding

Biological Process: regulation of immune response; viral reproduction; immune response; signal transduction

Disease: Systemic Lupus Erythematosus; Malaria, Susceptibility To