Western Blot (WB)
(Western Blot analysis of FBXL5 expression in transfected 293T cell line by FBXL5 polyclonal antibody. Lane 1: FBXL5 transfected lysate (76.01kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human FBXL5 Polyclonal Antibody | anti-FBXL5 antibody
FBXL5 (FBL4, FBL5, FLR1, F-box/LRR-repeat Protein 5, F-box and Leucine-rich Repeat Protein 5, F-box Protein FBL4/FBL5, p45SKP2-like Protein)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of FBXL5 expression in transfected 293T cell line by FBXL5 polyclonal antibody. Lane 1: FBXL5 transfected lysate (76.01kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of FBXL5 expression in transfected 293T cell line by FBXL5 polyclonal antibody. Lane 1: FBXL5 transfected lysate (76.01kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]
Uniprot Description
FBXL5: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 4p15.32
Cellular Component: perinuclear region of cytoplasm; SCF ubiquitin ligase complex; ubiquitin ligase complex
Molecular Function: protein binding; iron ion binding; ubiquitin-protein ligase activity
Biological Process: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; iron ion homeostasis; protein ubiquitination
Research Articles on FBXL5
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Product Notes
The FBXL5 fbxl5 (Catalog #AAA643903) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The FBXL5 (FBL4, FBL5, FLR1, F-box/LRR-repeat Protein 5, F-box and Leucine-rich Repeat Protein 5, F-box Protein FBL4/FBL5, p45SKP2-like Protein) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FBXL5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the FBXL5 fbxl5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MAPFPEEVDV FTAPHWRMKQ LVGLYCDKLS KTNFSNNNDF RALLQSLYAT FTEFKMHEQI ENEYIIGLLQ QRSQTIYNVH SDNKLSEMLS LFEKGLKNVK NEYEQLNYAK QLKERLEAFT RDFLPHMKEE EEVFQPMLME YFTYEELKDI KKKVIAQHCS QKDTAELLRG LSLWNHAEER QKFFKYSVDE KSDKEAEVSE HSTGITHLPP EVMLSIFSYL NPQELCRCSQ VSMKWSQLTK TRSLWKHLYP VHWARGDWYS GPATELDTEP DDEWVKNRKD ESRAFHEWDE DADIDESEES AEESIAISIA QMEKRLLHGL IHNVLPYVGT SVKTLVLAYS SAVSSKMVRQ ILELCPNLEH LDLTQTDISD SAFDSWSWLG CCQSLRHLDL SGCEKITDVA LEKISRALGI LTSHQSGFLK TSTSKITSTA WKNKDITMQS TKQYACLHDL TNKGIGEEID NEHPWTKPVS SENFTSPYVW MLDAEDLADI EDTVEWRHRN VESLCVMETA SNFSCSTSGC FSKDIVGLRT SVCWQQHCAS PAFAYCGHSF CCTGTALRTM SSLPESSAMC RKAARTRLPR GKDLIYFGSE KSDQETGRVL LFLSLSGCYQ ITDHGLRVLT LGGGLPYLEH LNLSGCLTIT GAGLQDLVSA CPSLNDEYFY YCDNINGPHA DTASGCQNLQ CGFRACCRSG E. It is sometimes possible for the material contained within the vial of "FBXL5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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