Rabbit FBXL14 Polyclonal Antibody | anti-FBXL14 antibody

FBXL14 Rabbit Polyclonal

Cat. Num. AAA769265

• Gene Names: FBXL14; Fbl14
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: FBXL14; Polyclonal Antibody; FBXL14 Rabbit Polyclonal; anti-FBXL14 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 418

• Applicable Applications for anti-FBXL14 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: F-box and leucine-rich repeat protein 14
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver using MBS769265 (FBXL14 antibody) at dilution of 1:50)

Western Blot (WB)

(HepG2 cells were subjected to SDS PAGE followed by western blot with MBS769265 (FBXL14 antibody) at dilution of 1:800)

NCBI and Uniprot Product Information

• NCBI GI #: 22748931
• NCBI GeneID: 144699
• NCBI Accession #: NP_689654.1
• NCBI GenBank Nucleotide #: NM_152441.2
• Molecular Weight: 45,886 Da
• NCBI Official Full Name: F-box/LRR-repeat protein 14
• NCBI Official Synonym Full Names: F-box and leucine rich repeat protein 14
• NCBI Official Symbol: FBXL14
• NCBI Official Synonym Symbols: Fbl14
• NCBI Protein Information: F-box/LRR-repeat protein 14
• UniProt Protein Name: F-box/LRR-repeat protein 14
• UniProt Gene Name: FBXL14
• UniProt Synonym Gene Names: FBL14
• UniProt Entry Name: FXL14_HUMAN

NCBI Description

Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Uniprot Description

FBXL14: Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.

Chromosomal Location of Human Ortholog: 12p13.33

Cellular Component: cytoplasm; Golgi apparatus; nucleoplasm

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process