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Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human liver tissue using MBS7046325 at dilution 1:100)

Rabbit anti-Human FASTK Polyclonal Antibody | anti-FASTK antibody

FASTK Antibody

Gene Names
FASTK; FAST
Reactivity
Human
Applications
ELISA, Immunohistochemistry
Purity
Antigen Affinity Purified
Synonyms
FASTK; Polyclonal Antibody; FASTK Antibody; Fas-activated serine/threonine kinase; FAST kinase; anti-FASTK antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Sequence Length
522
Applicable Applications for anti-FASTK antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
Recommended dilution: IHC: 1:20-1:200
Species
Human
Immunogen
Recombinant human Fas-activated serine/threonine kinase protein (C-190AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-31145 / sc-1820 / sc-22770
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver tissue using MBS7046325 at dilution 1:100)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human liver tissue using MBS7046325 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human brain tissue using MBS7046325 at dilution 1:100)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human brain tissue using MBS7046325 at dilution 1:100)
Related Product Information for anti-FASTK antibody
Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
57,576 Da
NCBI Official Full Name
fas-activated serine/threonine kinase isoform 5
NCBI Official Synonym Full Names
Fas activated serine/threonine kinase
NCBI Official Symbol
FASTK
NCBI Official Synonym Symbols
FAST
NCBI Protein Information
fas-activated serine/threonine kinase
UniProt Protein Name
Fas-activated serine/threonine kinase
UniProt Gene Name
FASTK
UniProt Synonym Gene Names
FAST kinase
UniProt Entry Name
FASTK_HUMAN

NCBI Description

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

FASTK: an atypical protein kinase. Fas-mediated apoptosis is characterized by FASTK- dephosphorylation and TIA-1-phosphorylation. Both are activated and FASTK-mediated TIA-1 activation play a key role in apoptosis.

Protein type: EC 2.7.11.8; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, atypical; ATYPICAL group; FAST family

Chromosomal Location of Human Ortholog: 7q35

Molecular Function: protein binding; protein serine/threonine kinase activity

Biological Process: protein amino acid phosphorylation; regulation of RNA splicing

Research Articles on FASTK

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Product Notes

The FASTK fastk (Catalog #AAA7046325) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FASTK Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FASTK can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Recommended dilution: IHC: 1:20-1:200. Researchers should empirically determine the suitability of the FASTK fastk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FASTK, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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