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Western Blot (WB) (FANCG Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the FANCG antibody detected the FANCG protein (arrow).)

Rabbit anti-Human FANCG Polyclonal Antibody | anti-FANCG antibody

FANCG, CT (FANCG, XRCC9, Fanconi anemia group G protein, DNA repair protein XRCC9) (PE)

Gene Names
FANCG; FAG; XRCC9
Reactivity
Human
Applications
Immunohistochemistry, Western Blot
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
FANCG; Polyclonal Antibody; CT (FANCG; XRCC9; Fanconi anemia group G protein; DNA repair protein XRCC9) (PE); DNA repair protein XRCC9; anti-FANCG antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Applicable Applications for anti-FANCG antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.
Immunogen
FANCG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 539-568 amino acids from the C-terminal region of human FANCG.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(FANCG Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the FANCG antibody detected the FANCG protein (arrow).)

Western Blot (WB) (FANCG Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the FANCG antibody detected the FANCG protein (arrow).)

Immunohistochemistry (IHC)

(FANCG Antibody (C-term) (AP14683b)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FANCG Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Immunohistochemistry (IHC) (FANCG Antibody (C-term) (AP14683b)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FANCG Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Related Product Information for anti-FANCG antibody
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G.
Product Categories/Family for anti-FANCG antibody
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Wang, C., et al. Biochemistry 49(26):5560-5569(2010). Monsees, G.M., et al. Breast Cancer Res. Treat. (2010). In press: Lipkin, S.M., et al. Cancer Prev Res (Phila) 3(5):597-603(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
68,554 Da
NCBI Official Full Name
Fanconi anemia group G protein
NCBI Official Synonym Full Names
Fanconi anemia, complementation group G
NCBI Official Symbol
FANCG
NCBI Official Synonym Symbols
FAG; XRCC9
NCBI Protein Information
Fanconi anemia group G protein; DNA repair protein XRCC9; X-ray repair, complementing defective, in Chinese hamster, 9; X-ray repair complementing defective repair in Chinese hamster cells 9
UniProt Protein Name
Fanconi anemia group G protein
UniProt Gene Name
FANCG
UniProt Synonym Gene Names
XRCC9; Protein FACG
UniProt Entry Name
FANCG_HUMAN

NCBI Description

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008]

Uniprot Description

FANCG: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. Defects in FANCG are a cause of Fanconi anemia complementation group G (FANCG). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleolus; plasma membrane

Molecular Function: protein binding; damaged DNA binding

Biological Process: mitochondrion organization and biogenesis; response to radiation; ovarian follicle development; DNA repair; cell cycle checkpoint; spermatid development

Disease: Fanconi Anemia, Complementation Group G; Tracheoesophageal Fistula With Or Without Esophageal Atresia

Research Articles on FANCG

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Product Notes

The FANCG fancg (Catalog #AAA6298009) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FANCG, CT (FANCG, XRCC9, Fanconi anemia group G protein, DNA repair protein XRCC9) (PE) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FANCG can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), FLISA, Western Blot (WB). IHC: 1:10-50 FLISA: 1:1,000 WB: 1:100-500 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the FANCG fancg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FANCG, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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