Western Blot (WB)
(Anti-FAF1 antibody, MBS175742, Western blottingLane 1: Rat Testis Tissue LysateLane 2: MM453 Cell LysateLane 3: MM231 Cell LysateLane 4: HELA Cell LysateLane 5: SMMC Cell LysateLane 6: SW620 Cell Lysate )
Rabbit FAF1 Polyclonal Antibody | anti-FAF1 antibody
Anti-FAF1 antibody
Western Blot (WB)
(Anti-FAF1 antibody, MBS175742, Western blottingLane 1: Rat Testis Tissue LysateLane 2: MM453 Cell LysateLane 3: MM231 Cell LysateLane 4: HELA Cell LysateLane 5: SMMC Cell LysateLane 6: SW620 Cell Lysate )
Western Blot (WB)
(Anti-FAF1 antibody, MBS175742, Western blottingLane 1: Rat Testis Tissue LysateLane 2: MM453 Cell LysateLane 3: MM231 Cell LysateLane 4: HELA Cell LysateLane 5: SMMC Cell LysateLane 6: SW620 Cell Lysate )
Background: Fas-associated factor-1(FAF1) is a Fas-binding pro-apoptotic protein that is a component of the death-inducing signaling complex in Fas-mediated apoptosis. FAF1 is involved in negative regulation of NF-kappaB activation. In addition to the previously known function as a component of the Fas death-inducing signaling complex, i.e. NF-kappaB activity suppressor by cytoplasmic retention of NF-kappaB p65 via physical interaction. hFAF1 was expressed abundantly in testis, skeletal muscle, and heart as 2.8 kb mRNA. Polyclonal antibody against hFAF1 detected 74 kD protein, a deduced protein size from the ORF and 40 kD protein in some cell lines.
NCBI and Uniprot Product Information
NCBI Description
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]
Uniprot Description
FAF1: a pro-apoptotic protein that binds to FAS antigen. Potentiates but cannot initiate FAS-induced apoptosis. Its pro-apoptotic activity requires a ubiquitin-like domain but not the FAS-binding domain. Phosphorylation by protein kinase CK2 influences transport into nucleus. Two transcript variants encoding different protein isoforms have been described.
Protein type: Nuclear receptor co-regulator; Apoptosis
Chromosomal Location of Human Ortholog: 1p33
Cellular Component: perinuclear region of cytoplasm; CD95 death-inducing signaling complex; nuclear envelope; nucleus; cytosol
Molecular Function: protein domain specific binding; NF-kappaB binding; ubiquitin binding; protein binding; heat shock protein binding; ubiquitin protein ligase binding; protein kinase regulator activity; protein kinase binding
Biological Process: regulation of cell adhesion; cell death; proteasomal ubiquitin-dependent protein catabolic process; cytoplasmic sequestering of NF-kappaB; positive regulation of protein complex assembly; positive regulation of apoptosis; apoptosis; regulation of protein catabolic process; regulation of protein kinase activity
Research Articles on FAF1
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Product Notes
The FAF1 faf1 (Catalog #AAA175742) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-FAF1 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's FAF1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the FAF1 faf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FAF1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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