Sheep anti-Human F2 / Prothrombin / Thrombin Polyclonal Antibody | anti-F2 antibody

Anti-F2 / Prothrombin / Thrombin Antibody IHC-plus

Cat. Num. AAA2400173

• Gene Names: F2; PT; THPH1; RPRGL2
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Serum
• Synonyms: F2 / Prothrombin / Thrombin; Polyclonal Antibody; Anti-F2 / Prothrombin / Thrombin Antibody IHC-plus; Sheep Polyclonal (IgG) to Human F2 / Prothrombin / Thrombin; Human F2 / Prothrombin / Thrombin; Prothrombin B-chain; Coagulation factor II; FACTOR II; Prothrombin; PT; RPRGL2; Serine protease; THPH1; Thrombin; anti-F2 antibody

• Host: Sheep
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Prothrombin.
• Purity/Purification: Serum
• Form/Format: 0.01 M HEPES, pH 7.4, 150mM sodium chloride, 50% glycerol. No preservative added.
• Sequence Length: 622

• Applicable Applications for anti-F2 antibody: Immunohistochemistry (IHC) Paraffin, ELISA (EIA), Immunoelectrophoresis (IEP)
• Application Notes: IHC-P (1:100)
• Immunogen: F2 / Prothrombin / Thrombin antibody was raised against human Prothrombin (Factor II) purified from plasma.
• Immunogen Description: Human Prothrombin (Factor II) purified from plasma.
• Immunogen Type: Purified protein
• Target Species: Human
• Preparation and Storage: Long term: -20 degree C; Short term: 4 degree C; Avoid repeat freeze-thaw cycles

Immunohistochemistry (IHC)

(Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-F2 antibody

F2 Antibody, Prothrombin B-chain Antibody, Coagulation factor II Antibody, FACTOR II Antibody, Prothrombin Antibody, PT Antibody, RPRGL2 Antibody, Serine protease Antibody, THPH1 Antibody, Thrombin Antibody Description: Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Finally, peptides derived from the C-terminus of this protein have antimicrobial activity against E Coli and P. aeruginosa. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

NCBI and Uniprot Product Information

• NCBI GI #: 4503635
• NCBI GeneID: 2147
• NCBI Accession #: NP_000497.1
• NCBI GenBank Nucleotide #: NM_000506.4
• UniProt Accession #: P00734; Q4QZ40; Q53H04; Q53H06; Q69EZ7; Q7Z7P3; Q9UCA1; B2R7F7; B4E1A7
• Molecular Weight: 70,037 Da
• NCBI Official Full Name: prothrombin isoform 1 preproprotein
• NCBI Official Synonym Full Names: coagulation factor II, thrombin
• NCBI Official Symbol: F2
• NCBI Official Synonym Symbols: PT; THPH1; RPRGL2
• NCBI Protein Information: prothrombin
• UniProt Protein Name: Prothrombin
• Protein Family: Prothrombin
• UniProt Gene Name: F2
• UniProt Entry Name: THRB_HUMAN

NCBI Description

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Uniprot Description

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.