Western Blot (WB)
(EVI1 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the EVI1 antibody detected the EVI1 protein (arrow).)
Rabbit anti-Human EVI1 Polyclonal Antibody | anti-MECOM antibody
EVI1, NT (MECOM, EVI1, MDS1 and EVI1 complex locus protein EVI1, Ecotropic virus integration site 1 protein homolog)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(EVI1 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the EVI1 antibody detected the EVI1 protein (arrow).)
Western Blot (WB)
(EVI1 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the EVI1 antibody detected the EVI1 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Uniprot Description
EVI1: a zinc finger transcriptional regulator that binds to DNA sequences in the promoter region of target genes and positively or negatively regulates their expression. An oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Originally identified as a common site of viral integration in murine myeloid leukemia. Involved in human myeloid disorders through chromosome translocation and inversion and is also implicated in solid tumor formation. At least six isoforms of the human protein are formed due to alternative usage of 5'-ends, alternative splicing, and intergenic splicing which results in the formation of a fusion protein with MDS1, which can be expressed in normal tissues.
Protein type: Transcription, coactivator/corepressor; C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Oncoprotein; Transcription regulation
Chromosomal Location of Human Ortholog: 3q26.2
Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; cytoplasm; histone deacetylase complex; nuclear speck; nucleus
Molecular Function: protein binding; protein homodimerization activity; DNA binding; metal ion binding; transcription factor activity
Biological Process: embryonic forelimb morphogenesis; pericardium development; negative regulation of JNK cascade; transcription, DNA-dependent; apoptosis; in utero embryonic development; regulation of cell cycle; positive regulation of transcription, DNA-dependent; neutrophil homeostasis; embryonic hindlimb morphogenesis; regulation of cell proliferation; post-embryonic development; response to bacterium; regulation of transcription, DNA-dependent; forebrain development; negative regulation of programmed cell death; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of transcription, DNA-dependent; inflammatory response
Research Articles on MECOM
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Product Notes
The MECOM mecom (Catalog #AAA643412) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The EVI1, NT (MECOM, EVI1, MDS1 and EVI1 complex locus protein EVI1, Ecotropic virus integration site 1 protein homolog) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's EVI1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the MECOM mecom for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EVI1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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