Rabbit anti-Human ET-3 Polyclonal Antibody | anti-ET-3 antibody

Anti-ET-3 Antibody

Cat. Num. AAA8306539

• Gene Names: EDN3; ET3; ET-3; WS4B; HSCR4; PPET3
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Immunogen Affinity Chromatography
• Synonyms: ET-3; Polyclonal Antibody; Anti-ET-3 Antibody; Endothelin-3; Preproendothelin-3; PPET3; anti-ET-3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of ET-3 protein.
• Purity/Purification: Purified by Immunogen Affinity Chromatography
• Form/Format: Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

• Applicable Applications for anti-ET-3 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant fusion protein of human ET-3. The exact sequence is proprietary.
• Preparation and Storage: Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of ET-3 expression in A549 (A) whole cell lysates.)

Related Product Information for anti-ET-3 antibody

Rabbit polyclonal antibody to ET-3

NCBI and Uniprot Product Information

• NCBI GI #: 698848571
• NCBI GeneID: 1908
• NCBI Accession #: NP_001289384.1
• NCBI GenBank Nucleotide #: NM_001302455.1
• UniProt Accession #: P14138; Q03229; Q7Z6D2; Q9UGT7; E1P5I5
• Molecular Weight: 23,596 Da
• NCBI Official Full Name: endothelin-3 isoform 4 preproprotein
• NCBI Official Synonym Full Names: endothelin 3
• NCBI Official Symbol: EDN3
• NCBI Official Synonym Symbols: ET3; ET-3; WS4B; HSCR4; PPET3
• NCBI Protein Information: endothelin-3
• UniProt Protein Name: Endothelin-3
• UniProt Gene Name: EDN3
• UniProt Synonym Gene Names: ET-3; PPET3
• UniProt Entry Name: EDN3_HUMAN

Uniprot Description

EDN3: Endothelins are endothelium-derived vasoconstrictor peptides. Defects in EDN3 are the cause of Hirschsprung disease type 4 (HSCR4); also known as aganglionic megacolon (MGC). A genetic disorder of neural crest development characterized by the absence of intramural ganglion cells in the hindgut; often resulting in intestinal obstruction. Defects in EDN3 are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. Defects in EDN3 are a cause of Waardenburg syndrome type 4 (WS4B); also known as Waardenburg-Shah syndrome. WS4B is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease). Belongs to the endothelin/sarafotoxin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.2-q13.3

Cellular Component: extracellular region; extracellular space

Molecular Function: endothelin B receptor binding; hormone activity; receptor binding

Biological Process: artery smooth muscle contraction; blood circulation; cell surface receptor linked signal transduction; cell-cell signaling; inositol phosphate-mediated signaling; multicellular organismal development; neutrophil chemotaxis; peptide hormone secretion; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of heart rate; positive regulation of hormone secretion; positive regulation of leukocyte chemotaxis; positive regulation of MAP kinase activity; positive regulation of mitosis; regulation of gene expression; regulation of systemic arterial blood pressure by endothelin; signal transduction; vasoconstriction; vein smooth muscle contraction

Disease: Central Hypoventilation Syndrome, Congenital; Hirschsprung Disease, Susceptibility To, 4; Waardenburg Syndrome, Type 4b