Western Blot (WB)
(Western blot analysis of extracts of 293 cells, using Estrogen R ? antibody.)
Rabbit ESR1 Polyclonal Antibody | anti-ESR1 antibody
ESR1 Antibody
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
Antigen affinity purification
Synonyms
ESR1; Polyclonal Antibody; ESR1 Antibody; DKFZp686N23123; ER; ESR; ESRA; Era; NR3A1; Estrogen Receptor ?; anti-ESR1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen affinity purification
Concentration
1mg/mL (varies by lot)
Sequence Length
229
Applicable Applications for anti-ESR1 antibody
Western Blot (WB)
Immunogen
Recombinant protein of human ESR1
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-542 / sc-543 / sc-544 / sc-7207
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Western Blot (WB)
(Western blot analysis of extracts of 293 cells, using Estrogen R ? antibody.)
Western Blot (WB)
(Western blot analysis of extracts of 293 cells, using Estrogen R ? antibody.)
Testing Data #2
Testing Data #2
Related Product Information for anti-ESR1 antibody
Estrogen receptor alpha (ERalpha), a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD) (1). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ERalpha regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery (2). Phosphorylation provides an important mechanism to regulate ERalpha activity (3, 4). ERalpha is phosphorylated on multiple sites (5). Ser104, 106, 118 and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serines plays an important role in regulating ERalpha activity. Ser118 may be the substrate of the transcription regulatory kinase CDK7 (5). Ser167 may be phosphorylated by p90RSK and Akt (4, 6). Phosphorylation of Ser167 may confer tamoxifen resistance in breast cancer patients (4).
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
25,913 Da
NCBI Official Full Name
ESR1, partial
UniProt Protein Name
ESR1
Protein Family
UniProt Gene Name
ESR1
UniProt Entry Name
A2T781_PANTR
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Product Notes
The ESR1 esr1 (Catalog #AAA2519048) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ESR1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ESR1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the ESR1 esr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ESR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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