Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Rat Erythropoietin Receptor (EPOR) Polyclonal Antibody | anti-EPOR antibody
Polyclonal Antibody to Erythropoietin Receptor (EPOR)
MGHHHHHHSGSEF-LWWSPSS PFPEDPPAHL EVLSERRWGV TQAGDAGAED KGPLLEPVGS ERAQDTYLVL DEWLLPRCPC SENLSGPGDS VDPATMDEGS ETSSCPSDLA SKPRPEGTSP SSFEYTILDP SSKLLCPRAL PPELPPTPPH LKYLYLVVSD SGISTDY
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:RatTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:RatTissue))
NCBI and Uniprot Product Information
NCBI Description
binds erythropoietin and induces an increase in cytosolic calcium ion concentration [RGD, Feb 2006]
Uniprot Description
EPOR: erythropoietin receptor: a member of the cytokine receptor family. Mediates erythropoietin-induced erythroblast proliferation, differentiation and survival. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. Forms homodimers on EPO stimulation. Tyrosine-phosphorylated EpoR may bind several SH2 domain-containing proteins including LYN, the adapter protein APS, SHP-1, SHP-2, JAK2, PI3 kinases, STAT5A/B, SOCS3, and CRKL. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Three alternatively-spliced isoforms have been described. Isoform EPOR-T, missing the cytoplasmic tail, acts as a dominant-negative receptor of EPOR-mediated signaling.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 8q13
Cellular Component: cytoplasm; external side of plasma membrane; integral component of membrane
Molecular Function: erythropoietin receptor activity; identical protein binding
Biological Process: aging; brain development; cellular response to kainic acid; decidualization; elevation of cytosolic calcium ion concentration; erythropoietin-mediated signaling pathway; heart development; negative regulation of neuron apoptosis; negative regulation of nitric oxide biosynthetic process; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron projection development; response to hypoxia; signal transduction
Research Articles on EPOR
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Product Notes
The EPOR epor (Catalog #AAA2005204) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Erythropoietin Receptor (EPOR) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Erythropoietin Receptor (EPOR) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the EPOR epor for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF-LWWSPS S PFPEDPPAHL EVLSERRWGV TQAGDAGAED KGPLLEPVGS ERAQDTYLVL DEWLLPRCPC SENLSGPGDS VDPATMDEGS ETSSCPSDLA SKPRPEGTSP SSFEYTILDP SSKLLCPRAL PPELPPTPPH LKYLYLVVSD SGISTDY. It is sometimes possible for the material contained within the vial of "Erythropoietin Receptor (EPOR), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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