Rabbit anti-Mouse ERP72 Polyclonal Antibody | anti-PDIL1-3 antibody

ERP72 (PDIA4, Protein Disulfide-isomerase A4, Endoplasmic Reticulum Resident Protein 70, ER Protein 70, ERp70, Endoplasmic Reticulum Resident Protein 72, ER Protein 72, ERp-72, ERp72, ERP70)

Cat. Num. AAA6006159

• Gene Names: PDIL1-3; ARABIDOPSIS THALIANA PROTEIN DISULFIDE ISOMERASE 1; ATPDI1; ATPDIL1-3; PDI-like 1-3; PDI1; PDIL1-3; PROTEIN DISULFIDE ISOMERASE 1; T15C9.4
• Reactivity: Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: ERP72; Polyclonal Antibody; ERP72 (PDIA4; Protein Disulfide-isomerase A4; Endoplasmic Reticulum Resident Protein 70; ER Protein 70; ERp70; Endoplasmic Reticulum Resident Protein 72; ER Protein 72; ERp-72; ERp72; ERP70); Anti -ERP72 (PDIA4; anti-PDIL1-3 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Specificity: Recognizes mouse PDIA4. Species sequence homology: Bovine, Canine, Guinea pig, Hamster, Human, Monkey, Rabbit, Rat.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.

• Applicable Applications for anti-PDIL1-3 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Western Blot: 1:1000; Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
• Immunogen: Synthetic peptide corresponding to mouse ERp72 aa623-638 with a cysteine residue added conjugated to KLH.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Brain, cerebellum, Human: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Placenta, Human: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Prostate, Human: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Testis, Human: Formalin-Fixed, Paraffin-Embedded (FFPE))

Western Blot (WB)

(Western Blot Analysis of ERp72: Lane 1: MW Marker, Lane 2: Rat Liver Microsome Extract, Lane 3: Mouse Liver Microsome Extract, Lane 4: Human Liver Microsome Extract.)

Related Product Information for anti-PDIL1-3 antibody

PDIA4, also known as ERP72, is an endoplasmic reticulum luminal protein that is both a stress protein and a member of the protein disulfide isomerase family of proteins. It is involved in the catalysis of protein-S-S-bond rearrangement. PDIA3 and PDIA4 act as proteases, protein disulfide isomerases, phospholipases or a combination of these.

Product Categories/Family for anti-PDIL1-3 antibody

Antibodies; Abs to Enzymes; Isomerase

NCBI and Uniprot Product Information

• NCBI GI #: 18072841
• NCBI GeneID: 824661
• UniProt Accession #: Q8VX13; Q9SV44; B3H5N9
• Molecular Weight: 64,212 Da
• NCBI Official Full Name: ERp72
• NCBI Official Symbol: PDIL1-3
• NCBI Official Synonym Symbols: ARABIDOPSIS THALIANA PROTEIN DISULFIDE ISOMERASE 1; ATPDI1; ATPDIL1-3; PDI-like 1-3; PDI1; PDIL1-3; PROTEIN DISULFIDE ISOMERASE 1; T15C9.4
• NCBI Protein Information: protein PDI-like 1-3
• UniProt Protein Name: Protein disulfide isomerase-like 1-3
• Protein Family: Protein disulfide isomerase
• UniProt Gene Name: PDIL1-3
• UniProt Synonym Gene Names: PDI1; PDI72; PDIL2-1; AtPDIL1-3; AtPDI1; AtPDIL2-1
• UniProt Entry Name: PDI13_ARATH

NCBI Description

Encodes a protein disulfide isomerase-like (PDIL) protein, a member of a multigene family within the thioredoxin (TRX) superfamily. Transcript levels for this gene are up-regulated in response to three different chemical inducers of ER stress (dithiothreitol, beta-mercaptoethanol, and tunicamycin). Neither AtIRE1-2 nor AtbZIP60 appear to be required for this response.

Uniprot Description

Function: Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds

By similarity.

Catalytic activity: Catalyzes the rearrangement of -S-S- bonds in proteins.

Subcellular location: Endoplasmic reticulum lumen

Probable.

Tissue specificity: Widely expressed. Ref.7

Induction: By chemically-induced ER stress response. Ref.7

Sequence similarities: Belongs to the protein disulfide isomerase family.Contains 2 thioredoxin domains.

Sequence caution: The sequence CAB41088.1 differs from that shown. Reason: Erroneous gene model prediction.