Western Blot (WB)
(Western blot analysis of 1) Hela, 2)293T, 3)3T3, 4)Mouse Skeletal Muscle, 5)Rat Kidney, 6) Rat Skeletal Muscle with ERK5 Rabbit pAb E12-344 diluted at 1:2, 000.)
ERK5 Polyclonal Antibody | anti-ERK5 antibody
ERK5 Rabbit Polyclonal Antibody (F139)
Western Blot (WB)
(Western blot analysis of 1) Hela, 2)293T, 3)3T3, 4)Mouse Skeletal Muscle, 5)Rat Kidney, 6) Rat Skeletal Muscle with ERK5 Rabbit pAb E12-344 diluted at 1:2, 000.)
Western Blot (WB)
(Western blot analysis of 1) Hela, 2)293T, 3)3T3, 4)Mouse Skeletal Muscle, 5)Rat Kidney, 6) Rat Skeletal Muscle with ERK5 Rabbit pAb E12-344 diluted at 1:2, 000.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
Research Articles on ERK5
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Product Notes
The ERK5 mapk7 (Catalog #AAA8510393) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The ERK5 Rabbit Polyclonal Antibody (F139) reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ERK5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:1,000-2,000. Researchers should empirically determine the suitability of the ERK5 mapk7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERK5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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