Chicken anti-Human ERK5 Polyclonal Antibody | anti-MAPK7 antibody

ERK5 (Extracellular Signal-regulated Kinase 5, ERK-5, Big MAP Kinase 1, BMK1, BMK-1, Mitogen-activated Protein Kinase 7, MAP Kinase 7, MAPK 7, MAPK7, PRKM7)

Cat. Num. AAA616226

• Gene Names: MAPK7; BMK1; ERK4; ERK5; PRKM7
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: ERK5; Polyclonal Antibody; ERK5 (Extracellular Signal-regulated Kinase 5; ERK-5; Big MAP Kinase 1; BMK1; BMK-1; Mitogen-activated Protein Kinase 7; MAP Kinase 7; MAPK 7; MAPK7; PRKM7); Anti -ERK5 (Extracellular Signal-regulated Kinase 5; anti-MAPK7 antibody

• Host: Chicken
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgY
• Specificity: Recognizes human Erk5.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide. Glycerol free.

• Applicable Applications for anti-MAPK7 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot. May be suitable for use in Immunohistochemistry and Immunocytochemistry.; Dilution: Western Blot: 1:500
• Immunogen: Synthetic peptide corresponding to aa341-570 of human Erk5 Protein GI Number: 20986497. Protein Accession #: NP_002740.2
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western Blot: E coli-derived fusion protein as test antigen. MBS616226 (1:2000), Goat anti-IgY-HRP (1:1000). Colorimetric method for signal development.)

Related Product Information for anti-MAPK7 antibody

Erk5 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals. They are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. Erk5 kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. This transcript variant (3) is also known as BMK1 gamma. It contains a different 5' UTR, and encodes the identical isoform (1), as compared to variant 1.

Product Categories/Family for anti-MAPK7 antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 20986497
• NCBI GeneID: 5598
• NCBI Accession #: NP_002740.2
• NCBI GenBank Nucleotide #: NM_002749.3
• UniProt Accession #: Q13164; Q16634; Q59F50; Q6QLU7; Q7L4P4; Q969G1; Q96G51
• Molecular Weight: 88,386 Da
• NCBI Official Full Name: mitogen-activated protein kinase 7 isoform 1
• NCBI Official Synonym Full Names: mitogen-activated protein kinase 7
• NCBI Official Symbol: MAPK7
• NCBI Official Synonym Symbols: BMK1; ERK4; ERK5; PRKM7
• NCBI Protein Information: mitogen-activated protein kinase 7; BMK-1; ERK-5; MAPK 7; BMK1 kinase; MAP kinase 7; big MAP kinase 1; OTTHUMP00000065906; OTTHUMP00000065907; extracellular signal-regulated kinase 5; extracellular-signal-regulated kinase 5
• UniProt Protein Name: Mitogen-activated protein kinase 7
• UniProt Gene Name: MAPK7
• UniProt Synonym Gene Names: BMK1; ERK5; PRKM7
• UniProt Entry Name: MK07_HUMAN

NCBI Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq]

Uniprot Description

ERK5: a protein kinase of the MAPK family. Phosphorylated and activated by MEK5. Involved in the signaling processes downstream of various receptors including receptor tyrosine kinases and G protein-coupled receptors. Translocates to cell nucleus in response to extracelluar signals, where it regulates gene expression by phosphorylating various transcription factors. Mouse knockout shows a role in development and integrity of blood vessels. May block apoptosis in endothelial cells. Required for transduction of EGF growth signal, constitutively activated in ErbB2-overexpressing breast cancer, and downstream of activated Mek5 in metastatic prostate cancerFour alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.

Protein type: Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.24; CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: nucleoplasm; PML body; cytoplasm; cytosol; nucleus

Molecular Function: MAP kinase activity; protein binding; mitogen-activated protein kinase binding; ATP binding

Biological Process: negative regulation of cAMP catabolic process; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; positive regulation of protein metabolic process; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; cAMP-mediated signaling; cell differentiation; toll-like receptor 4 signaling pathway; negative regulation of heterotypic cell-cell adhesion; MyD88-independent toll-like receptor signaling pathway; negative regulation of NFAT protein import into nucleus; cell cycle; regulation of angiogenesis; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; negative regulation of inflammatory response; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; negative regulation of cyclic-nucleotide phosphodiesterase activity