Rabbit anti-Mouse ERBB2 Polyclonal Antibody | anti-ERBB2 antibody
ERBB2 (Phospho-Ser1114) (Mouse) Rabbit pAb
Gene Names
Erbb2; Neu; HER2; HER-2; c-neu; Erbb-2; c-erbB2; l11Jus8; mKIAA3023
Reactivity
Mouse
Applications
Dot Blot
Purity
Affinity Purified
Synonyms
ERBB2; Polyclonal Antibody; ERBB2 (Phospho-Ser1114) (Mouse) Rabbit pAb; Receptor tyrosine-protein kinase erbB-2; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; p185erbB2; CD340; Erbb2; Kiaa3023; Neu; anti-ERBB2 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
Ig
Clone Number
RB40082
Purity/Purification
Affinity Purified
Form/Format
Supplied in PBS with 0.09% (W/V) Sodium Azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Sequence Length
1256
Applicable Applications for anti-ERBB2 antibody
Dot Blot (DB)
Application Notes
DB: 1:500
Immunogen
This mouse ERBB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1114 of mouse ERBB2.
Cellular Localization
Cell Membrane, Cytoplasm, Membrane, Nucleus
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
receptor tyrosine-protein kinase erbB-2
NCBI Official Synonym Full Names
erb-b2 receptor tyrosine kinase 2
NCBI Official Symbol
Erbb2
NCBI Official Synonym Symbols
Neu; HER2; HER-2; c-neu; Erbb-2; c-erbB2; l11Jus8; mKIAA3023
NCBI Protein Information
receptor tyrosine-protein kinase erbB-2
UniProt Protein Name
Receptor tyrosine-protein kinase erbB-2
Protein Family
UniProt Gene Name
Erbb2
UniProt Synonym Gene Names
Kiaa3023; Neu
Uniprot Description
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization ().
Research Articles on ERBB2
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Product Notes
The ERBB2 erbb2 (Catalog #AAA8554304) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ERBB2 (Phospho-Ser1114) (Mouse) Rabbit pAb reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ERBB2 can be used in a range of immunoassay formats including, but not limited to, Dot Blot (DB). DB: 1:500. Researchers should empirically determine the suitability of the ERBB2 erbb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERBB2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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