Western Blot (WB)
(Anti-ErbB 4 antibody, MBS176131, Western blottingLane 1: A549 Cell LysateLane 2: HELA Cell Lysate )
Rabbit ErbB 4 Polyclonal Antibody | anti-ERBB4 antibody
Anti-ErbB 4 antibody
Western Blot (WB)
(Anti-ErbB 4 antibody, MBS176131, Western blottingLane 1: A549 Cell LysateLane 2: HELA Cell Lysate )
Western Blot (WB)
(Anti-ErbB 4 antibody, MBS176131, Western blottingLane 1: A549 Cell LysateLane 2: HELA Cell Lysate )
Western Blot (WB)
(Anti-ErbB 4 antibody, MBS176131, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant human ERRB4, 40.6KD(162aa tag+M1-P200)Lane 1: Recombinant Human ERRB4 Protein 10ngLane 2: Recombinant Human ERRB4 Protein 5ngLane 3: Recombinant Human ERRB4 Protein 2.5ngLane 4: Recombinant Human ERRB4 Protein 1.25ng )
Western Blot (WB)
(Anti-ErbB 4 antibody, MBS176131, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant human ERRB4, 40.6KD(162aa tag+M1-P200)Lane 1: Recombinant Human ERRB4 Protein 10ngLane 2: Recombinant Human ERRB4 Protein 5ngLane 3: Recombinant Human ERRB4 Protein 2.5ngLane 4: Recombinant Human ERRB4 Protein 1.25ng )
Western Blot (WB)
(Anti-ErbB 4 antibody, MBS176131, Western blottingLane 1: HELA Cell LysateLane 2: U87 Cell LysateLane 3: NEURO Cell Lysate )
Western Blot (WB)
(Anti-ErbB 4 antibody, MBS176131, Western blottingLane 1: HELA Cell LysateLane 2: U87 Cell LysateLane 3: NEURO Cell Lysate )
Background: ERBB4(V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) also known as ONCOGENE ERBB4 or HER4, is an enzyme that in humans is encoded by the ERBB4 gene. The HER4/ERBB4 gene is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, ERBB2 and ERBB3. The ERBB4 gene is mapped on 2q34. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domainbinding motif. Huang et al.(2000) reported that ERBB4 is enriched in the postsynaptic density and associates with PSD95. ERBB4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding its ligand, heregulin, or activation of protein kinase C by TPA, the ERBB4 ectodomain is cleaved by a metalloprotease. Ni et al.(2001)concluded that gamma-secretase cleavage of ERBB4 may represent another mechanism for receptor tyrosine kinase-mediated signaling.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
HER4: a receptor tyrosine kinase of the EGFR family. Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Heterodimerizes and signals with other EGF receptors. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with WWOX. May act as a tumor suppressor: overexpressed in head and neck cancer , but downregulated in renal cancer, papillary carcinoma, high-grade gliomas and invasive breast cancer. 3 alternatively-spliced isoforms of the human protein have been reported.
Protein type: Protein kinase, TK; EC 2.7.10.1; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; EGFR family
Chromosomal Location of Human Ortholog: 2q33.3-q34
Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; basolateral plasma membrane; extracellular region; integral to membrane; plasma membrane; cytosol; nucleus; receptor complex
Molecular Function: protein binding; protein homodimerization activity; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; epidermal growth factor receptor binding
Biological Process: lactation; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; heart development; protein amino acid autophosphorylation; positive regulation of transcription, DNA-dependent; embryonic pattern specification; signal transduction; olfactory bulb interneuron differentiation; regulation of cell migration; negative regulation of cell proliferation; positive regulation of cell proliferation; neural crest cell migration; positive regulation of cardiac muscle cell proliferation; epidermal growth factor receptor signaling pathway; nervous system development; cell migration; cell fate commitment; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; transcription, DNA-dependent; positive regulation of phosphoinositide 3-kinase activity; cell proliferation; central nervous system morphogenesis; positive regulation of tyrosine phosphorylation of Stat5 protein; innate immune response; mitochondrial fragmentation during apoptosis; positive regulation of protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
Disease: Amyotrophic Lateral Sclerosis 19
Research Articles on ERBB4
Similar Products
Product Notes
The ERBB4 erbb4 (Catalog #AAA176131) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ErbB 4 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ErbB 4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the ERBB4 erbb4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ErbB 4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
