Western Blot (WB)
(Western Blot analysis of extracts of various cell lines, using EPS15L1 antibody.)
Rabbit anti-Human EPS15L1 Polyclonal Antibody | anti-EPS15L1 antibody
EPS15L1 Polyclonal Antibody
Gene Names
EPS15L1; EPS15R
Reactivity
Human
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
EPS15L1; Polyclonal Antibody; EPS15L1 Polyclonal Antibody; EPS15R; Epidermal growth factor receptor substrate 15-like 1; anti-EPS15L1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
EPS15L1 polyclonal antibody detects endogenous levels of EPS15L1 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
910
Applicable Applications for anti-EPS15L1 antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:2000
Immunogen
Recombinant protein of human EPS15L1.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot analysis of extracts of various cell lines, using EPS15L1 antibody.)
Western Blot (WB)
(Western Blot analysis of extracts of various cell lines, using EPS15L1 antibody.)
Related Product Information for anti-EPS15L1 antibody
EPS15L1 (Epidermal Growth Factor Receptor Pathway Substrate 15-Like 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and EGFR1 Signaling Pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is ITSN1. Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 110kDa
NCBI Official Full Name
epidermal growth factor receptor substrate 15-like 1 isoform 1
NCBI Official Synonym Full Names
epidermal growth factor receptor pathway substrate 15 like 1
NCBI Official Symbol
EPS15L1
NCBI Official Synonym Symbols
EPS15R
NCBI Protein Information
epidermal growth factor receptor substrate 15-like 1
UniProt Protein Name
Epidermal growth factor receptor substrate 15-like 1
Protein Family
UniProt Gene Name
EPS15L1
UniProt Synonym Gene Names
EPS15R; Eps15R
UniProt Entry Name
EP15R_HUMAN
Uniprot Description
EPS15R: epidermal growth factor receptor substrate protein 15R. Contains three EH domains which are implicated in endocytosis, vesicle transport and signal transduction. All three EH domains contain calcium-binding domains ofthe EF-hand type. Contains 2 UIM motifs, which are is responsible for ubiquitin recognition and monoubiquitination. May function as an adaptor between ubiquitinated proteins and the clathrin coat or other endocytic scaffolds.
Protein type: Adaptor/scaffold; Vesicle
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: membrane; plasma membrane; coated pit; nucleus
Molecular Function: protein binding; calcium ion binding
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; endocytosis
Research Articles on EPS15L1
Similar Products
Product Notes
The EPS15L1 eps15l1 (Catalog #AAA3008901) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The EPS15L1 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's EPS15L1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the EPS15L1 eps15l1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EPS15L1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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