Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human lung tissue using MBS719788 at dilution 1:100)
Rabbit anti-Human Endothelial protein C receptor Polyclonal Antibody | anti-PROCR antibody
Rabbit anti-human Endothelial protein C receptor polyclonal Antibody
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human lung tissue using MBS719788 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human lung tissue using MBS719788 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney tissue using MBS719788 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney tissue using MBS719788 at dilution 1:100)
Western Blot (WB)
(Western blotAll lanes: PROCRantibody at 2ug/ml+ Mouse lung tissueGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 26 kDaObserved band size: 26 kDa)
Western Blot (WB)
(Western blotAll lanes: PROCRantibody at 2ug/ml+ Mouse lung tissueGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 26 kDaObserved band size: 26 kDa)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]
Uniprot Description
EPCR: a single-pass type I membrane protein. Binds activated protein C (APC), a serine protease that regulates thrombin (IIa) production. Plays a pivotal role in preventing blood coagulation through binding of activated protein C. Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. The binding of APC to EPCR and PAR-1 increases invasion and chemotaxis.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 20q11.2
Cellular Component: cell surface; centrosome; extracellular region; focal adhesion; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; receptor activity
Biological Process: blood coagulation; immune response; leukocyte migration; negative regulation of coagulation
Research Articles on PROCR
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Product Notes
The PROCR procr (Catalog #AAA719788) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Endothelial protein C receptor polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Endothelial protein C receptor can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the PROCR procr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Endothelial protein C receptor, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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