Rabbit anti-Human Endoplasmic Reticulum To Nucleus Signalling 1 (ERN1) Polyclonal Antibody | anti-ERN1 antibody
Biotin-Linked Polyclonal Antibody to Endoplasmic Reticulum To Nucleus Signalling 1 (ERN1)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
Uniprot Description
IRE1: a ser/thr protein kinase that possess endonuclease activity. Important in altering gene expression as a response to endoplasmic reticulum based stress signals. Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain, which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain. Ubiquitously expressed. High levels observed in pancreatic tissue. Functionally connected with insulin biosynthesis in pancreatic beta cells. Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges. Also binds HSPA5, a negative regulator of the unfolded protein response. This interaction may disrupt homodimerization and prevent activation of IRE1.
Protein type: Apoptosis; Chaperone; EC 2.7.11.1; Endoplasmic reticulum; IRE family; Kinase, protein; Membrane protein, integral; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Ribonuclease
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component: AIP1-IRE1 complex; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; integral component of endoplasmic reticulum membrane; Ire1 complex; IRE1-RACK1-PP2A complex; IRE1-TRAF2-ASK1 complex; mitochondrion; nuclear inner membrane
Molecular Function: ADP binding; ATP binding; endoribonuclease activity; enzyme binding; Hsp70 protein binding; Hsp90 protein binding; identical protein binding; magnesium ion binding; platelet-derived growth factor receptor binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity
Biological Process: activation of JNK activity; activation of signaling protein activity involved in unfolded protein response; cell cycle arrest; cellular response to glucose stimulus; endothelial cell proliferation; insulin metabolic process; IRE1-mediated unfolded protein response; mRNA catabolic process; mRNA cleavage; peptidyl-serine trans-autophosphorylation; positive regulation of endoplasmic reticulum unfolded protein response; positive regulation of RNA splicing; positive regulation of vascular smooth muscle cell proliferation; protein amino acid phosphorylation; protein autophosphorylation; regulation of macroautophagy; regulation of transcription, DNA-templated; RNA phosphodiester bond hydrolysis, endonucleolytic; transcription, DNA-dependent
Research Articles on ERN1
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Product Notes
The ERN1 ern1 (Catalog #AAA2094535) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to Endoplasmic Reticulum To Nucleus Signalling 1 (ERN1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Endoplasmic Reticulum To Nucleus Signalling 1 (ERN1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the ERN1 ern1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Endoplasmic Reticulum To Nucleus Signalling 1 (ERN1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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