Rabbit anti-Human EML4 Polyclonal Antibody | anti-EML4 antibody

EML4 Rabbit pAb

Cat. Num. AAA4758093

• Gene Names: EML4; C2orf2; ELP120; EMAP-4; EMAPL4; ROPP120
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: EML4; Polyclonal Antibody; EML4 Rabbit pAb; echinoderm microtubule associated protein like 4; C2orf2; ELP120; EMAP-4; EMAPL4; ROPP120; anti-EML4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-EML4 antibody: ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: ELISA: 1:5000-1:10,000; IHC: 1:25-1:100
• Immunogen: Full length fusion protein
• Conjugation: Unconjugated
• Modification: Unmodified
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 823638(EML4 Antibody) at dilution 1/35. (Original magnification: ×200))

Related Product Information for anti-EML4 antibody

This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants.

Product Categories/Family for anti-EML4 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 223029510
• NCBI GeneID: 27436
• NCBI Accession #: NP_001138548.1
• NCBI GenBank Nucleotide #: NM_001145076.1
• UniProt Accession #: Q9HC35; Q3SWW0; Q53R29; Q53TW8; Q6PJ45; Q9NV40; A6H8Y6; B2RBK3; B2RTW7; B5MCW9
• Molecular Weight: 108,916 Da
• NCBI Official Full Name: echinoderm microtubule-associated protein-like 4 isoform b
• NCBI Official Synonym Full Names: echinoderm microtubule associated protein like 4
• NCBI Official Symbol: EML4
• NCBI Official Synonym Symbols: C2orf2; ELP120; EMAP-4; EMAPL4; ROPP120
• NCBI Protein Information: echinoderm microtubule-associated protein-like 4; ropp 120; restrictedly overexpressed proliferation-associated protein
• UniProt Protein Name: Echinoderm microtubule-associated protein-like 4
• Protein Family: Echinoderm microtubule-associated protein
• UniProt Gene Name: EML4
• UniProt Synonym Gene Names: C2orf2; EMAPL4; EMAP-4
• UniProt Entry Name: EMAL4_HUMAN

NCBI Description

This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]

Uniprot Description

Function: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic

By similarity.

Subcellular location: Cytoplasm › cytoskeleton

Potential.

Developmental stage: Strongly overexpressed during mitosis.

Sequence similarities: Belongs to the WD repeat EMAP family.Contains 9 WD repeats.

Sequence caution: The sequence AAI04648.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.The sequence BAA91919.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.