Rabbit anti-Human ELOVL5 Polyclonal Antibody | anti-ELOVL5 antibody

ELOVL5, CT (ELOVL5, ELOVL2, Elongation of very long chain fatty acids protein 5, 3-keto acyl-CoA synthase ELOVL5, ELOVL fatty acid elongase 5, Fatty acid elongase 1) (MaxLight 650)

Cat. Num. AAA6295399

• Gene Names: ELOVL5; HELO1; SCA38; dJ483K16.1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ELOVL5; Polyclonal Antibody; CT (ELOVL5; ELOVL2; Elongation of very long chain fatty acids protein 5; 3-keto acyl-CoA synthase ELOVL5; ELOVL fatty acid elongase 5; Fatty acid elongase 1) (MaxLight 650); Fatty acid elongase 1; anti-ELOVL5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

• Applicable Applications for anti-ELOVL5 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: ELOVL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-277 amino acids from the C-terminal region of human ELOVL5.
• Conjugate: MaxLight650
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-ELOVL5 antibody

ELOVL5 plays a role in elongation of long-chain polyunsaturated fatty acids (Leonard et al., 2000 [PubMed 10970790]).

Product Categories/Family for anti-ELOVL5 antibody

Antibodies; Enzymes; Synthase

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Meguro, A., et al. Ophthalmology 117(7):1331-1338(2010). Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008). Lamesch, P., et al. Genomics 89(3):307-315(2007). Olsen, J.V., et al. Cell 127(3):635-648(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 11464975
• NCBI GeneID: 60481
• NCBI Accession #: NP_068586.1
• NCBI GenBank Nucleotide #: NM_021814.4
• UniProt Accession #: Q9NYP7; Q59EL3; Q5TGH5; Q6NXE7; Q7L2S5; Q8NCG4; Q9UI22; B4DZJ2; F6SH78
• Molecular Weight: 9,580 Da
• NCBI Official Full Name: elongation of very long chain fatty acids protein 5 isoform 1
• NCBI Official Synonym Full Names: ELOVL fatty acid elongase 5
• NCBI Official Symbol: ELOVL5
• NCBI Official Synonym Symbols: HELO1; SCA38; dJ483K16.1
• NCBI Protein Information: elongation of very long chain fatty acids protein 5; ELOVL FA elongase 5; fatty acid elongase 1; spinocerebellar ataxia 38; 3-keto acyl-CoA synthase ELOVL5; very-long-chain 3-oxoacyl-CoA synthase 5; homolog of yeast long chain polyunsaturated fatty acid e
• UniProt Protein Name: Elongation of very long chain fatty acids protein 5
• UniProt Gene Name: ELOVL5
• UniProt Synonym Gene Names: ELOVL2; ELOVL FA elongase 5; hELO1
• UniProt Entry Name: ELOV5_HUMAN

NCBI Description

This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Uniprot Description

ELOVL5: Condensing enzyme that catalyzes the synthesis of monounsaturated and of polyunsaturated very long chain fatty acids Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. Belongs to the ELO family.

Protein type: Lipid Metabolism - unsaturated fatty acid biosynthesis; EC 2.3.1.199; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p12.1

Cellular Component: endoplasmic reticulum membrane; membrane; cell soma; endoplasmic reticulum; dendrite; integral to membrane

Molecular Function: protein binding; fatty acid elongase activity

Biological Process: unsaturated fatty acid metabolic process; very-long-chain fatty acid biosynthetic process; linoleic acid metabolic process; unsaturated fatty acid biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process

Disease: Spinocerebellar Ataxia 38