Rabbit ELOVL1 Polyclonal Antibody | anti-ELOVL1 antibody

ELOVL1 (F139) Polyclonal Antibody

Cat. Num. AAA3003439

• Gene Names: ELOVL1; Ssc1; IKSHD; CGI-88
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: ELOVL1; Polyclonal Antibody; ELOVL1 (F139) Polyclonal Antibody; Elongation of very long chain fatty acids protein 1; 3-keto acyl-CoA synthase ELOVL1; ELOVL fatty acid elongase 1; ELOVL FA elongase 1; Very-long-chain 3-oxoacyl-CoA synthase 1; CGI-88; CGI88; SSC1; anti-ELOVL1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ELOVL1 (F139) polyclonal antibody detects endogenous levels of ELOVL1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 279

• Applicable Applications for anti-ELOVL1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 104-156 of Human ELOVL1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of ELOVL1 (F139) pAb at 1:500 dilutionLane1:MCF-7 whole cell lysate (40ug) Lane2:HEK293T whole cell lysate (40ug) Lane3:Hela whole cell lysate (40ug) Lane4:The Kidney tissue lysate of Mouse (40ug) Lane5:The Kidney tissue lysate of Rat (40ug))

Western Blot (WB)

(Western Blot (WB) analysis of ELOVL1 (F139) pAb at 1:500 dilutionLane1:HEK293T whole cell lysate (40ug) Lane2:HepG2 whole cell lysate (40ug) Lane3:The kidney tissue lysate of Rat (30ug) Lane4:The kidney tissue lysate of Mouse (30ug))

Related Product Information for anti-ELOVL1 antibody

Elongation of very long chain fatty acid-like (ELOVL) proteins 1-6 are members of the ELO family of proteins, which play an important role in tissue-specific biosynthesis of very long chain fatty acids and sphingolipids. The ELOVL proteins act as catalysts in fatty acid elongation reduction and localize to the endoplasmic reticulum (ER). Elongation of very long chain fatty acids protein 1 (ELOVL1), also referred to as Ssc1, is the human homolog of the yeast ELO3 protein. It is expressed in a variety of tissues and at especially high levels in stomach, skin, intestine, kidney and lung. ELOVL1 participates in the elongation of very long chain saturated and monounsaturated fatty acids of up to 26 carbons and may be required for the development of a barrier in epithelial cells and skin. ELOVL1 is also important for the formation of Myelin in the central nervous system. Impaired ELOVL1 activity may be associated with disorders of sphingolipid metabolism.

NCBI and Uniprot Product Information

• NCBI GI #: 373938448
• NCBI GeneID: 64834
• NCBI Accession #: NP_001243328.1
• NCBI GenBank Nucleotide #: NP_001243328.1
• UniProt Accession #: Q9BW60
• Molecular Weight: ~ 35kDa
• NCBI Official Full Name: elongation of very long chain fatty acids protein 1 isoform 1
• NCBI Official Synonym Full Names: ELOVL fatty acid elongase 1
• NCBI Official Symbol: ELOVL1
• NCBI Official Synonym Symbols: Ssc1; IKSHD; CGI-88
• NCBI Protein Information: elongation of very long chain fatty acids protein 1
• UniProt Protein Name: Elongation of very long chain fatty acids protein 1
• Protein Family: Elongation of very long chain fatty acids protein
• UniProt Gene Name: ELOVL1
• UniProt Synonym Gene Names: SSC1; ELOVL FA elongase 1
• UniProt Entry Name: ELOV1_HUMAN

Uniprot Description

ELOVL1: Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Belongs to the ELO family.

Protein type: EC 2.3.1.199; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p34.2

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to endoplasmic reticulum membrane

Molecular Function: protein binding; fatty acid elongase activity

Biological Process: sphingolipid biosynthetic process; very-long-chain fatty acid biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; fatty acid elongation, saturated fatty acid