Rabbit anti-Human, Mouse ELK4 Polyclonal Antibody | anti-ELK4 antibody

ELK4 Antibody

Cat. Num. AAA9629819

• Gene Names: ELK4; SAP1
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: ELK4; Polyclonal Antibody; ELK4 Antibody; anti-ELK4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: ELK4 Antibody detects endogenous levels of ELK4.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-ELK4 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human ELK4.
• Conjugation: Unconjugated
• Similarity: Belongs to the ETS family.
• Subunit Structure: Interacts with SIRT7.
• Function: Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-ELK4 antibody

Nucleus; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 41872448
• NCBI GeneID: 2005
• NCBI Accession #: NP_001964.2
• NCBI GenBank Nucleotide #: NM_001973.3
• UniProt Accession #: P28324; P28323; Q6GSJ2
• Molecular Weight: 44,674 Da
• NCBI Official Full Name: ETS domain-containing protein Elk-4 isoform a
• NCBI Official Synonym Full Names: ELK4, ETS transcription factor
• NCBI Official Symbol: ELK4
• NCBI Official Synonym Symbols: SAP1
• NCBI Protein Information: ETS domain-containing protein Elk-4
• UniProt Protein Name: ETS domain-containing protein Elk-4
• Protein Family: ETS domain-containing protein
• UniProt Gene Name: ELK4
• UniProt Synonym Gene Names: SAP1; SAP-1; SRF accessory protein 1

NCBI Description

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.