Western Blot (WB)
(Western blot analysis of A) human lymph node B) human tonsil and C) mouse thymus tissue lysates (35ug protein in RIPA buffer) probed with ELF1 antibody (0.3ug/ml,MBS226146) and detected by chemiluminescence.)
Goat anti-Human ELF1 Polyclonal Antibody | anti-ELF1 antibody
Goat anti ELF1
0.02% Sodium Azide
0.5% Bovine Serum Albumin
Purified IgG - liquid
WB: 0.03ug/ml to 0.1ug/ml
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
Western Blot (WB)
(Western blot analysis of A) human lymph node B) human tonsil and C) mouse thymus tissue lysates (35ug protein in RIPA buffer) probed with ELF1 antibody (0.3ug/ml,MBS226146) and detected by chemiluminescence.)
Western Blot (WB)
(Western blot analysis of A) human lymph node B) human tonsil and C) mouse thymus tissue lysates (35ug protein in RIPA buffer) probed with ELF1 antibody (0.3ug/ml,MBS226146) and detected by chemiluminescence.)
Western Blot (WB)
(Western blot analysis of Jurkat cell lysate (35ug protein in RIPA buffer) probed with ELF1 antibody (0.1ug/ml,MBS226146) and detected by chemiluminescence.)
Western Blot (WB)
(Western blot analysis of Jurkat cell lysate (35ug protein in RIPA buffer) probed with ELF1 antibody (0.1ug/ml,MBS226146) and detected by chemiluminescence.)
ELF1 is a small zinc-finger protein conserved in eukaryotes and some archaea (Ehara and Sekine 2018). ELF1 is ubiquitously expressed in human cells and is a member of the ETS family of transcription factors (Budka et al. 2018) and appears to act downstream of the DNA damage response pathway (Cheng et al. 2020). In cancer, ELF1 appears to have oncogenic and tumor suppressive functions depending on context (Budka et al. 2018). ELF1 appears to play an antiviral role, with lower levels of ELF1 reducing host defense against the influenza A virus (Seifert et al. 2019).
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Uniprot Description
Elf-1: Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. Belongs to the ETS family.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 13q13
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of T cell receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; regulation of cytokine production
Research Articles on ELF1
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Product Notes
The ELF1 elf1 (Catalog #AAA226146) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti ELF1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ELF1 can be used in a range of immunoassay formats including, but not limited to, Immunohistology-Paraffin (P), Western Blot (WB). P: 2.5ug/ml WB: 0.03ug/ml to 0.1ug/ml. Researchers should empirically determine the suitability of the ELF1 elf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ELF1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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