Rabbit EIF4G2 Polyclonal Antibody | anti-EIF4G2 antibody

EIF4G2 Polyclonal Antibody

Cat. Num. AAA8568328

• Gene Names: EIF4G2; P97; AAG1; DAP5; NAT1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: EIF4G2; Polyclonal Antibody; EIF4G2 Polyclonal Antibody; anti-EIF4G2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
• Sequence Length: 869

• Applicable Applications for anti-EIF4G2 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: A synthetic peptide of human EIF4G2 (NP_001409.3).
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Related Product Information for anti-EIF4G2 antibody

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

NCBI and Uniprot Product Information

• NCBI GI #: 289577114
• NCBI GeneID: 1982
• NCBI Accession #: NP_001036024.3
• NCBI GenBank Nucleotide #: NP_001036024.3
• UniProt Accession #: P78344
• Molecular Weight: 98kDa; 102kDa
• NCBI Official Full Name: eukaryotic translation initiation factor 4 gamma 2 isoform 2
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 4 gamma 2
• NCBI Official Symbol: EIF4G2
• NCBI Official Synonym Symbols: P97; AAG1; DAP5; NAT1
• NCBI Protein Information: eukaryotic translation initiation factor 4 gamma 2
• UniProt Protein Name: Eukaryotic translation initiation factor 4 gamma 2
• Protein Family: Eukaryotic translation initiation factor
• UniProt Gene Name: EIF4G2
• UniProt Synonym Gene Names: DAP5; eIF-4-gamma 2; eIF-4G 2; eIF4G 2; DAP-5
• UniProt Entry Name: IF4G2_HUMAN

NCBI Description

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

EIF4G2: a general repressor of translation by forming translationally inactive complexes. Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Interacts with the protein kinases Mnk1 and -2. Binds EIF4A and EIF3. Cleaved by some caspases and viral proteases.

Protein type: Translation initiation; RNA-binding; Translation

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: membrane; eukaryotic translation initiation factor 4F complex; cytosol

Molecular Function: protein binding; translation factor activity, nucleic acid binding; translation initiation factor activity

Biological Process: cell death; cytokine and chemokine mediated signaling pathway; translational initiation; cell cycle arrest; regulation of translational initiation