Rabbit anti-Human EIF4EBP2 Polyclonal Antibody | anti-EIF4EBP2 antibody

EIF4EBP2, CT (EIF4EBP2, Eukaryotic translation initiation factor 4E-binding protein 2) (AP)

Cat. Num. AAA6295105

• Gene Names: EIF4EBP2; 4EBP2; PHASII
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: EIF4EBP2; Polyclonal Antibody; CT (EIF4EBP2; Eukaryotic translation initiation factor 4E-binding protein 2) (AP); Eukaryotic translation initiation factor 4E-binding protein 2; anti-EIF4EBP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-EIF4EBP2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: EIF4EBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-115 amino acids from the C-terminal region of human EIF4EBP2.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(EIF4EBP2 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the EIF4EBP2 antibody detected the EIF4EBP2 protein (arrow).)

Related Product Information for anti-EIF4EBP2 antibody

This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection.

Product Categories/Family for anti-EIF4EBP2 antibody

Antibodies; Translation Initiation Factors

References

Bailey, S.D., et al. Diabetes Care (2010). In press: Bidinosti, M., et al. J. Biol. Chem. 285(25):19402-19408(2010). Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010): Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Gingras, A.C., et al. Virology 237(1):182-186(1997).

NCBI and Uniprot Product Information

• NCBI GI #: 4758260
• NCBI GeneID: 1979
• NCBI Accession #: NP_004087.1
• NCBI GenBank Nucleotide #: NM_004096.4
• UniProt Accession #: Q13542
• Molecular Weight: 12,939 Da
• NCBI Official Full Name: eukaryotic translation initiation factor 4E-binding protein 2
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 4E binding protein 2
• NCBI Official Symbol: EIF4EBP2
• NCBI Official Synonym Symbols: 4EBP2; PHASII
• NCBI Protein Information: eukaryotic translation initiation factor 4E-binding protein 2; 4E-BP2; eIF4E-binding protein 2; phosphorylated, heat and acid stable regulated by insulin protein II
• UniProt Protein Name: Eukaryotic translation initiation factor 4E-binding protein 2
• Protein Family: Eukaryotic translation initiation factor 4E-binding protein
• UniProt Gene Name: EIF4EBP2
• UniProt Synonym Gene Names: 4E-BP2; eIF4E-binding protein 2
• UniProt Entry Name: 4EBP2_HUMAN

NCBI Description

This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]

Uniprot Description

4E-BP2: eukaryotic translation initiation factor 4E binding protein 2

Protein type: Translation initiation; Translation

Chromosomal Location of Human Ortholog: 10q21-q22

Molecular Function: protein binding; eukaryotic initiation factor 4E binding

Biological Process: negative regulation of translational initiation; cAMP-mediated signaling; translation; insulin receptor signaling pathway