Rabbit anti-Human EIF2B3 Polyclonal Antibody | anti-EIF2B3 antibody

EIF2B3, CT (Eukaryotic Translation Initiation Factor 2B, Subunit 3 gamma, 58kD, Isoform CRA_e, cDNA FLJ12337 Fis, Clone MAMMA1002236, Highly Similar to Translation Initiation Factor EIF-2B gamma Subunit, hCG_18606) (MaxLight 490)

Cat. Num. AAA6475259

• Gene Names: EIF2B3; EIF-2B; EIF2Bgamma
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Ammonium Sulfate Precipitation.
• Synonyms: EIF2B3; Polyclonal Antibody; CT (Eukaryotic Translation Initiation Factor 2B; Subunit 3 gamma; 58kD; Isoform CRA_e; cDNA FLJ12337 Fis; Clone MAMMA1002236; Highly Similar to Translation Initiation Factor EIF-2B gamma Subunit; hCG_18606) (MaxLight 490); anti-EIF2B3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human EIF2B3.
• Purity/Purification: Purified by Ammonium Sulfate Precipitation.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
• Sequence Length: 283

• Applicable Applications for anti-EIF2B3 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-1:500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the C-terminal region of human EIF2B3 (KLH).
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of EIF2B3 (arrow) using rabbit polyclonal EIF2B3 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the EIF2B3 gene.)

Product Categories/Family for anti-EIF2B3 antibody

Antibodies; Translation Initiation Factors

References

1. van der Knaap, M.S., et al., Ann. Neurol. 51(2):264-270 (2002). 2. Kruger, M., et al., Proc. Natl. Acad. Sci. USA 97(15):8566-8571 (2000). 3. Gomez, E., et al., Mol. Cell. Biol. 20(11):3965-3976 (2000).

NCBI and Uniprot Product Information

• NCBI GI #: 48146687
• NCBI GeneID: 8891
• UniProt Accession #: Q9HA31; Q9NR50
• Molecular Weight: 31.511
• NCBI Official Full Name: EIF2B3
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 2B subunit gamma
• NCBI Official Symbol: EIF2B3
• NCBI Official Synonym Symbols: EIF-2B; EIF2Bgamma
• NCBI Protein Information: translation initiation factor eIF-2B subunit gamma
• UniProt Protein Name: EIF2B3 protein
• Protein Family: Translation initiation factor
• UniProt Gene Name: EIF2B3
• UniProt Entry Name: Q9HA31_HUMAN

NCBI Description

The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]