Rabbit EHMT2 Polyclonal Antibody | anti-EHMT2 antibody

EHMT2 (Euchromatic Histone-lysine N-methyltransferase 2, BAT8, C6orf30, DKFZp686H08213, FLJ35547, G9A, KMT1C, NG36, NG36/G9a) (MaxLight 650)

Cat. Num. AAA6415372

• Gene Names: EHMT2; G9A; BAT8; GAT8; NG36; KMT1C; C6orf30
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: EHMT2; Polyclonal Antibody; EHMT2 (Euchromatic Histone-lysine N-methyltransferase 2; BAT8; C6orf30; DKFZp686H08213; FLJ35547; G9A; KMT1C; NG36; NG36/G9a) (MaxLight 650); anti-EHMT2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes EHMT2. Species Crossreactivity: human, mouse, rat
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

• Applicable Applications for anti-EHMT2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide corresponding to human EHMT2.
• Conjugate: MaxLight650
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-EHMT2 antibody

Antibodies; Enzymes; Methyltransferase

NCBI and Uniprot Product Information

• NCBI GI #: 116241348
• NCBI GeneID: 10919
• UniProt Accession #: Q96KQ7; Q14349; Q5JP83; Q5JQ92; Q5JQA1; Q5JQG3; Q6PK06; Q96MH5; Q96QD0; Q9UQL8; Q9Y331; B0UZY2
• Molecular Weight: 1210
• NCBI Official Full Name: Histone-lysine N-methyltransferase EHMT2
• NCBI Official Synonym Full Names: euchromatic histone-lysine N-methyltransferase 2
• NCBI Official Symbol: EHMT2
• NCBI Official Synonym Symbols: G9A; BAT8; GAT8; NG36; KMT1C; C6orf30
• NCBI Protein Information: histone-lysine N-methyltransferase EHMT2; H3-K9-HMTase 3; G9A histone methyltransferase; HLA-B associated transcript 8; lysine N-methyltransferase 1C; ankyrin repeat-containing protein; histone H3-K9 methyltransferase 3; histone-lysine N-methyltransferase
• UniProt Protein Name: Histone-lysine N-methyltransferase EHMT2
• Protein Family: Histone-lysine N-methyltransferase
• UniProt Gene Name: EHMT2
• UniProt Synonym Gene Names: BAT8; C6orf30; G9A; KMT1C; NG36; H3-K9-HMTase 3
• UniProt Entry Name: EHMT2_HUMAN

NCBI Description

This gene is located in a gene cluster within the human major histocompatibility complex class III region on chromosome 6. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but recent publications show that there is only a single gene at this locus. The encoded protein is a histone methyltransferase, which may be involved in repression of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Description

EHMT2 iso4: Histone methyltransferase. Preferentially methylates 'Lys-9' of histone H3 and 'Lys-27' of histone H3 (in vitro). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. Also methylates histone H1. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with GFI1B, WIZ and EHMT1. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase, protein lysine; Amino Acid Metabolism - lysine degradation; Methyltransferase; EC 2.1.1.43

Chromosomal Location of Human Ortholog: 6p21.31

Cellular Component: nucleoplasm; intermediate filament cytoskeleton; intracellular membrane-bound organelle; nuclear chromatin; nucleus

Molecular Function: protein binding; zinc ion binding; p53 binding; histone lysine N-methyltransferase activity (H3-K9 specific); protein-lysine N-methyltransferase activity; histone-lysine N-methyltransferase activity; histone lysine N-methyltransferase activity (H3-K27 specific)

Biological Process: histone methylation; establishment and/or maintenance of chromatin architecture; peptidyl-lysine di-methylation; DNA methylation; negative regulation of transcription from RNA polymerase II promoter; regulation of DNA replication; histone H3-K9 methylation