Rabbit EGR2 Polyclonal Antibody | anti-EGR2 antibody

EGR2 Rabbit Polyclonal

Cat. Num. AAA768904

• Gene Names: EGR2; AT591; CMT1D; CMT4E; KROX20
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: EGR2; Polyclonal Antibody; EGR2 Rabbit Polyclonal; anti-EGR2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 426

• Applicable Applications for anti-EGR2 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Early growth response 2 (Krox-20 homolog, Drosophila)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS768904 (EGR2 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 1005261237
• NCBI GeneID: 1959
• NCBI Accession #: NP_001307966.1
• NCBI GenBank Nucleotide #: NM_001321037.1
• Molecular Weight: 44,970 Da
• NCBI Official Full Name: E3 SUMO-protein ligase EGR2 isoform b
• NCBI Official Synonym Full Names: early growth response 2
• NCBI Official Symbol: EGR2
• NCBI Official Synonym Symbols: AT591; CMT1D; CMT4E; KROX20
• NCBI Protein Information: E3 SUMO-protein ligase EGR2
• UniProt Protein Name: E3 SUMO-protein ligase EGR2
• Protein Family: E3 SUMO-protein ligase
• UniProt Gene Name: EGR2
• UniProt Synonym Gene Names: KROX20; EGR-2
• UniProt Entry Name: EGR2_HUMAN

NCBI Description

The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Uniprot Description

EGR2: Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Defects in EGR2 are a cause of congenital hypomyelination neuropathy (CHN). Inheritance can be autosomal dominant or recessive. Recessive CHN is also known as Charcot- Marie-Tooth disease type 4E (CMT4E). CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle weakness, and very slow nerve conduction velocities. Defects in EGR2 are a cause of Charcot-Marie-Tooth disease type 1D (CMT1D). CMT1D is a form of Charcot- Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. Defects in EGR2 are a cause of Dejerine-Sottas syndrome (DSS); also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie- Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome. Belongs to the EGR C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; EC 6.3.2.-; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 10q21.1

Cellular Component: cytoplasm; nucleus

Molecular Function: chromatin binding; ligase activity; metal ion binding; protein binding; transcription factor activity; ubiquitin protein ligase binding

Biological Process: brain development; brain segmentation; facial nerve structural organization; fat cell differentiation; learning and/or memory; motor axon guidance; myelination; peripheral nervous system development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein export from nucleus; protein sumoylation; regulation of neuronal synaptic plasticity; regulation of ossification; response to insulin stimulus; rhombomere 3 formation; rhombomere 5 formation; rhythmic behavior; Schwann cell differentiation; transcription from RNA polymerase II promoter

Disease: Charcot-marie-tooth Disease, Demyelinating, Type 1d; Hypertrophic Neuropathy Of Dejerine-sottas; Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive