Rabbit EFEMP1 Polyclonal Antibody | anti-EFEMP1 antibody

EFEMP1 Antibody FITC-Conjugated

Cat. Num. AAA541472

• Gene Names: EFEMP1; DHRD; DRAD; FBNL; MLVT; MTLV; S1-5; FBLN3; FIBL-3
• Reactivity: Human, Monkey, Mouse, Rat
• Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
• Synonyms: EFEMP1; Polyclonal Antibody; EFEMP1 Antibody FITC-Conjugated; DHRD; Doyne honeycomb retinal degeneration; DRAD; EFEMP 1; Epidermal growth factor containing fibulin like extracellular matrix protein 1; FBLN3; Fibrillin like; FIBULIN 3; FLJ35535; Heat shock 70 KD protein 1; MGC111353; MLVT; T16 protein antibody; anti-EFEMP1 antibody

• Host: Rabbit
• Reactivity: Human, Monkey, Mouse, Rat
• Clonality: Polyclonal
• Form/Format: FITC-Conjugated
• Concentration: 0.65 ug/ul in antibody stabilization buffer (varies by lot)
• Sequence Length: 543

• Applicable Applications for anti-EFEMP1 antibody: ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: Dot Blot: 1:10,000; ELISA: 1:10,000; Immunohistochemistry: 1:100; Immunoprecipitation: 1:200; Western Blot: 1:500
• Immunogen: Synthetic cyclic peptide corresponding to N terminal amino acids 25-42 of Human EFEMP1, peptide was covalently modified.; Sequence: TYTQCTDGYEWDPVRQQC
• Expression: In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.
• Molecular Function: Calcium
• Structure: Interacts with ECM1. Interacts with TIMP3.
• Subcellular Location: Secreted; Extracellular space
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for anti-EFEMP1 antibody

FITC-Conjugated EGF-containing fibulin-like extracellular matrix protein 1 Antibody
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.

NCBI and Uniprot Product Information

• NCBI GI #: 530367362
• NCBI GeneID: 2202
• NCBI Accession #: XP_005264262.1
• NCBI GenBank Nucleotide #: XM_005264205.4
• Molecular Weight: 39,195 Da
• NCBI Official Full Name: EGF-containing fibulin-like extracellular matrix protein 1 isoform X1
• NCBI Official Synonym Full Names: EGF containing fibulin like extracellular matrix protein 1
• NCBI Official Symbol: EFEMP1
• NCBI Official Synonym Symbols: DHRD; DRAD; FBNL; MLVT; MTLV; S1-5; FBLN3; FIBL-3
• NCBI Protein Information: EGF-containing fibulin-like extracellular matrix protein 1
• UniProt Protein Name: EGF-containing fibulin-like extracellular matrix protein 1
• Protein Family: EGF-containing fibulin-like extracellular matrix protein
• UniProt Gene Name: EFEMP1
• UniProt Synonym Gene Names: FBLN3; FBNL; FIBL-3
• UniProt Entry Name: FBLN3_HUMAN

NCBI Description

This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009]

Uniprot Description

EFEMP1: Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. Defects in EFEMP1 are a cause of Doyne honeycomb retinal dystrophy (DHRD); also known as malattia leventinese (MLVT) (ML). DHRD is an autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium. Belongs to the fibulin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p16

Cellular Component: basement membrane; cytoplasm; extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: calcium ion binding; epidermal growth factor receptor activity; epidermal growth factor receptor binding; growth factor activity; protein binding

Biological Process: camera-type eye development; embryonic eye morphogenesis; epidermal growth factor receptor signaling pathway; negative regulation of chondrocyte differentiation; peptidyl-tyrosine phosphorylation; positive regulation of cell projection organization and biogenesis; positive regulation of cell proliferation; post-embryonic eye morphogenesis; regulation of transcription, DNA-dependent; visual perception

Disease: Doyne Honeycomb Retinal Dystrophy