Western Blot (WB)
(Anti- EDNRB Picoband antibody, MBS178362, Western blottingAll lanes: Anti EDNRB (MBS178362) at 0.5ug/mlWB: HELA Whole Cell Lysate at 40ugPredicted bind size: 50KDObserved bind size: 50KD )
EDNRB Polyclonal Antibody | anti-EDNRB antibody
Anti-EDNRB Antibody
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
Western Blot (WB)
(Anti- EDNRB Picoband antibody, MBS178362, Western blottingAll lanes: Anti EDNRB (MBS178362) at 0.5ug/mlWB: HELA Whole Cell Lysate at 40ugPredicted bind size: 50KDObserved bind size: 50KD )
Western Blot (WB)
(Anti- EDNRB Picoband antibody, MBS178362, Western blottingAll lanes: Anti EDNRB (MBS178362) at 0.5ug/mlWB: HELA Whole Cell Lysate at 40ugPredicted bind size: 50KDObserved bind size: 50KD )
Immunohistochemistry (IHC)
(Anti- EDNRB Picoband antibody, MBS178362, IHC(P)IHC(P): Mouse Testis Tissue )
Immunohistochemistry (IHC)
(Anti- EDNRB Picoband antibody, MBS178362, IHC(P)IHC(P): Mouse Testis Tissue )
Immunohistochemistry (IHC)
(Anti- EDNRB Picoband antibody, MBS178362, IHC(P)IHC(P): Rat Testis Tissue )
Immunohistochemistry (IHC)
(Anti- EDNRB Picoband antibody, MBS178362, IHC(P)IHC(P): Rat Testis Tissue )
Immunohistochemistry (IHC)
(Anti- EDNRB Picoband antibody, MBS178362, IHC(P)IHC(P): Human Placenta Tissue )
Immunohistochemistry (IHC)
(Anti- EDNRB Picoband antibody, MBS178362, IHC(P)IHC(P): Human Placenta Tissue )
Background: Endothelin receptor type B, also known as ETB is a protein that in humans is encoded by the EDNRB gene. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Uniprot Description
ETB: a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. Essential component in the normal development of two neuronal crest-derived cell lineages. Two splice variant isoforms have been described.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q22
Cellular Component: cytosol; integral to plasma membrane; lipid raft; nuclear membrane; plasma membrane
Molecular Function: endothelin receptor activity; peptide hormone binding; protein binding; type 1 angiotensin receptor binding
Biological Process: aging; cell surface receptor linked signal transduction; cGMP-mediated signaling; elevation of cytosolic calcium ion concentration; enteric nervous system development; epithelial fluid transport; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); macrophage chemotaxis; melanocyte differentiation; negative regulation of adenylate cyclase activity; negative regulation of apoptosis; negative regulation of cellular protein metabolic process; negative regulation of neuron maturation; negative regulation of transcription from RNA polymerase II promoter; nervous system development; neural crest cell migration; peripheral nervous system development; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; posterior midgut development; regulation of blood pressure; regulation of epithelial cell proliferation; regulation of fever; regulation of pH; regulation of sensory perception of pain; response to organic cyclic substance; response to pain; sensory perception of pain; vasoconstriction; vasodilation; vein smooth muscle contraction
Disease: Abcd Syndrome; Hirschsprung Disease, Susceptibility To, 2; Waardenburg Syndrome, Type 4a
Research Articles on EDNRB
Similar Products
Product Notes
The EDNRB ednrb (Catalog #AAA178362) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-EDNRB Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's EDNRB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Western Blot Concentration: 0.1-0.5ug/ml Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml. Researchers should empirically determine the suitability of the EDNRB ednrb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EDNRB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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