Western Blot (WB)
(Western blot analysis of EDEM2 expression in HeLa (A) whole cell lysates.)
Rabbit anti-Human EDEM2 Polyclonal Antibody | anti-EDEM2 antibody
Anti-EDEM2 Antibody
Western Blot (WB)
(Western blot analysis of EDEM2 expression in HeLa (A) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of EDEM2 expression in HeLa (A) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM, Mar 2008]
Uniprot Description
EDEM2: Involved in endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. Belongs to the glycosyl hydrolase 47 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 20q11.22
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen; extracellular region
Molecular Function: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; calcium ion binding
Biological Process: cellular protein metabolic process; protein folding; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; response to unfolded protein
Research Articles on EDEM2
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Product Notes
The EDEM2 edem2 (Catalog #AAA8306538) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-EDEM2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's EDEM2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the EDEM2 edem2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EDEM2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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