Rabbit EAAT3 Polyclonal Antibody | anti-EAAT3 antibody

EAAT3 Rabbit Polyclonal

Cat. Num. AAA768838

• Gene Names: SLC1A1; DCBXA; EAAC1; EAAT3; SCZD18
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: EAAT3; Polyclonal Antibody; EAAT3 Rabbit Polyclonal; anti-EAAT3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 524

• Applicable Applications for anti-EAAT3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human brain using MBS768838 (SLC1A1 antibody) at dilution of 1:50)

Western Blot (WB)

(mouse ovary tissue were subjected to SDS PAGE followed by western blot with MBS768838 (SLC1A1 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 66773030
• NCBI GeneID: 6505
• NCBI Accession #: NP_004161.4
• NCBI GenBank Nucleotide #: NM_004170.5
• Molecular Weight: 57,100 Da
• NCBI Official Full Name: excitatory amino acid transporter 3
• NCBI Official Synonym Full Names: solute carrier family 1 member 1
• NCBI Official Symbol: SLC1A1
• NCBI Official Synonym Symbols: DCBXA; EAAC1; EAAT3; SCZD18
• NCBI Protein Information: excitatory amino acid transporter 3
• UniProt Protein Name: Excitatory amino acid transporter 3
• UniProt Gene Name: SLC1A1
• UniProt Synonym Gene Names: EAAC1; EAAT3
• UniProt Entry Name: EAA3_HUMAN

NCBI Description

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

Uniprot Description

SLC1A1: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily.

Protein type: Membrane protein, integral; Transporter; Transporter, SLC family; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9p24

Cellular Component: apical plasma membrane; integral to plasma membrane; membrane; plasma membrane

Molecular Function: amino acid transmembrane transporter activity; cysteine transmembrane transporter activity; glutamate binding; glutamate:sodium symporter activity; high-affinity glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity; protein binding; sodium:dicarboxylate symporter activity

Biological Process: cysteine transport; glutamate secretion; ion transport; L-glutamate import; positive regulation of heart rate; protein homooligomerization; synaptic transmission

Disease: Schizophrenia 18