Rabbit anti-Human E2IG3 Polyclonal Antibody | anti-E2IG3 antibody

E2IG3, ID (Nucleostemin, GNL3, Guanine Nucleotide-binding Protein-Like 3, Nucleolar GTP-binding Protein 3, Nucleostemin, E2-induced Gene 3 Protein, Novel Nucleolar Protein 47, NNP47, NS) (MaxLight 490)

Cat. Num. AAA6473425

• Gene Names: GNL3; NS; E2IG3; NNP47; C77032
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Ammonium Sulfate Precipitation.
• Synonyms: E2IG3; Polyclonal Antibody; ID (Nucleostemin; GNL3; Guanine Nucleotide-binding Protein-Like 3; Nucleolar GTP-binding Protein 3; Nucleostemin; E2-induced Gene 3 Protein; Novel Nucleolar Protein 47; NNP47; NS) (MaxLight 490); anti-E2IG3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human E2IG3.
• Purity/Purification: Purified by Ammonium Sulfate Precipitation.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
• Sequence Length: 549

• Applicable Applications for anti-E2IG3 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:50-1:100; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the center region of human E2IG3 (KLH).
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of anti-GNL3 Antibody (Center) (RB13797) in HL60 cell line lysates (35ug/lane). GNL3 (arrow) was detected using the purified Pab.)

Product Categories/Family for anti-E2IG3 antibody

Antibodies; Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 45593130
• NCBI GeneID: 26354
• NCBI Accession #: NP_055181
• NCBI GenBank Nucleotide #: NP_055181.3
• UniProt Accession #: Q9BVP2
• Molecular Weight: 61.997
• NCBI Official Full Name: guanine nucleotide-binding protein-like 3 isoform 1
• NCBI Official Synonym Full Names: G protein nucleolar 3
• NCBI Official Symbol: GNL3
• NCBI Official Synonym Symbols: NS; E2IG3; NNP47; C77032
• NCBI Protein Information: guanine nucleotide-binding protein-like 3
• UniProt Protein Name: Guanine nucleotide-binding protein-like 3
• UniProt Gene Name: GNL3
• UniProt Synonym Gene Names: E2IG3; NS
• UniProt Entry Name: GNL3_HUMAN

NCBI Description

The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Uniprot Description

GNL3: May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis. May interact with p53/TP53 via its basic domain. Increased levels in lung tissue in cancer patients. Belongs to the MMR1/HSR1 GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Cell cycle regulation; Nucleolus; RNA-binding

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: nucleoplasm; extracellular space; membrane; nucleolus; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding

Biological Process: cell proliferation; metabolic process; ribosome biogenesis and assembly; regulation of cell proliferation