Goat DUSP14/MKP6 Polyclonal Antibody | anti-DUSP14 antibody

Goat anti-DUSP14/MKP6 Antibody

Cat. Num. AAA421134

• Gene Names: DUSP14; MKP6; MKP-L
• Reactivity: Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
• Applications: ELISA
• Purity: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Synonyms: DUSP14/MKP6; Polyclonal Antibody; Goat anti-DUSP14/MKP6 Antibody; DUSP14; dual specificity phosphatase 14; MKP6; MKP-L; MKP-1 like protein tyrosine phosphatase; OTTHUMP00000164064; OTTHUMP00000164065; DUSP14 antibody; dual specificity phosphatase 14 antibody; MKP6 antibody; MKP-L antibody; MKP-1 like protein tyrosine phosphatase antibody; OTTHUMP00000164064 antibody; OTTHUMP00000164065 antibody; DUSP14 / MKP6; anti-DUSP14 antibody

• Host: Goat
• Reactivity: Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
• Clonality: Polyclonal
• Purity/Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Form/Format: Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: 100ug specific antibody in 200ul (varies by lot)
• Sequence: CEKESRHLMPYWGI
• Sequence Length: 198

• Applicable Applications for anti-DUSP14 antibody: Peptide ELISA (EIA)
• Application Notes: Peptide ELISA: Antibody detection limit dilution 1: 32000.; Western Blot: No signal obtained yet but low background observed in Human Liver extracts at up to 1ug/ml.
• Immunogen: Peptide with sequence CEKESRHLMPYWGI, from the C Terminus of the protein sequence according to NP_008957.1.
• Epitope: C Terminus
• Preparation and Storage: Aliquot and store at -20 degree C. Minimize freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 5902002
• NCBI GeneID: 11072
• NCBI Accession #: NP_008957.1
• NCBI GenBank Nucleotide #: NM_007026.3
• Molecular Weight: 22,255 Da
• NCBI Official Full Name: dual specificity protein phosphatase 14
• NCBI Official Synonym Full Names: dual specificity phosphatase 14
• NCBI Official Symbol: DUSP14
• NCBI Official Synonym Symbols: MKP6; MKP-L
• NCBI Protein Information: dual specificity protein phosphatase 14
• UniProt Protein Name: Dual specificity protein phosphatase 14
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP14
• UniProt Synonym Gene Names: MKP6; MKP-L; MAP kinase phosphatase 6; MKP-6
• UniProt Entry Name: DUS14_HUMAN

NCBI Description

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

Uniprot Description

MKP-6: a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (ERK, JNK, p38). Is a negative regulator of T cell costimulation via CD28.

Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 17q12

Molecular Function: MAP kinase tyrosine/serine/threonine phosphatase activity; protein binding; protein tyrosine phosphatase activity

Biological Process: inactivation of MAPK activity