Goat DUSP14 Polyclonal Antibody | anti-DUSP14 antibody

Goat Polyclonal to Human DUSP14

Cat. Num. AAA246811

• Gene Names: DUSP14; MKP6; MKP-L
• Reactivity: Bat, Gibbon, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rabbit, Rat; Predicted Reactivity: Bovine, Dog (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: DUSP14; Polyclonal Antibody; Goat Polyclonal to Human DUSP14; Anti-DUSP14 Antibody (C-Terminus) IHC-plus; DUSP 14; MKP-6; MKP-L; MAP kinase phosphatase 6; MKP6; Human DUSP14; anti-DUSP14 antibody

• Host: Goat
• Reactivity: Bat, Gibbon, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rabbit, Rat; Predicted Reactivity: Bovine, Dog (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human DUSP14.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 198

• Applicable Applications for anti-DUSP14 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:32000), IHC-P (3.5 ug/ml)
• Usage Not Recommended: Western Blot (WB)
• Target Species: Human
• Immunogen Description: Synthetic peptide C-EKESRHLMPYWGI from the C-terminus of human DUSP14 (NP_008957.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bat, Horse, Rabbit, Opossum (100%).
• Immunogen Type: Synthetic peptide
• Immunogen: DUSP14 antibody was raised against synthetic peptide C-EKESRHLMPYWGI from the C-terminus of human DUSP14 (NP_008957.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bat, Horse, Rabbit, Opossum (100%); Bovine, Dog (92%); Platypus (85%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-DUSP14 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.5 ug/ml.)

Related Product Information for anti-DUSP14 antibody

DUSP14 encodes a dual specificity MAP kinase phosphatase which has been shown to dephosphorylate ERK, JNK and p38 and to act as a negative regulator of CD28 signaling. DUSP14 has been mapped to chromosome 17q, a region known to have DNA copy number gains and amplifications in gastric cancer, and an increase of DUSP14 in gastric cancer has been demonstrated.

Product Categories/Family for anti-DUSP14 antibody

Family: Protein Phosphatase; Subfamily: Dual specificity MKP

NCBI and Uniprot Product Information

• NCBI GI #: 5902002
• NCBI GeneID: 11072
• NCBI Accession #: NP_008957.1
• NCBI GenBank Nucleotide #: NM_007026.3
• UniProt Accession #: O95147
• Molecular Weight: 22,255 Da
• NCBI Official Full Name: dual specificity protein phosphatase 14
• NCBI Official Synonym Full Names: dual specificity phosphatase 14
• NCBI Official Symbol: DUSP14
• NCBI Official Synonym Symbols: MKP6; MKP-L
• NCBI Protein Information: dual specificity protein phosphatase 14; MKP-6; MAP kinase phosphatase 6; MKP-1 like protein tyrosine phosphatase; MKP-1-like protein tyrosine phosphatase; mitogen-activated protein kinase phosphatase 6
• UniProt Protein Name: Dual specificity protein phosphatase 14
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP14
• UniProt Synonym Gene Names: MKP6; MKP-L; MAP kinase phosphatase 6; MKP-6
• UniProt Entry Name: DUS14_HUMAN

NCBI Description

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

Uniprot Description

MKP-6: a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (ERK, JNK, p38). Is a negative regulator of T cell costimulation via CD28.

Protein type: Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 17q12

Molecular Function: protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process: inactivation of MAPK activity