Western Blot (WB)
(DTX3L Antibody (Center) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the DTX3L antibody detected the DTX3L protein (arrow).)
Rabbit anti-Human DTX3L Polyclonal Antibody | anti-DTX3L antibody
DTX3L Antibody (Center)
Western Blot (WB)
(DTX3L Antibody (Center) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the DTX3L antibody detected the DTX3L protein (arrow).)
Western Blot (WB)
(DTX3L Antibody (Center) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the DTX3L antibody detected the DTX3L protein (arrow).)
al., 2003 [PubMed 12670957]).
Wilting, S.M., et al. Genes Chromosomes Cancer 47(10):890-905(2008)
Juszczynski, P., et al. Mol. Cell. Biol. 26(14):5348-5359(2006)
Takeyama, K., et al. J. Biol. Chem. 278(24):21930-21937(2003)
NCBI and Uniprot Product Information
NCBI Description
DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Uniprot Description
DTX3L: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 3q21.1
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein binding; histone binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: histone monoubiquitination; double-strand break repair; response to DNA damage stimulus
Research Articles on DTX3L
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Product Notes
The DTX3L dtx3l (Catalog #AAA9204326) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 453-482. The DTX3L Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DTX3L can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the DTX3L dtx3l for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DTX3L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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