Rabbit anti-Mouse DTNA Polyclonal Antibody | anti-DTNA antibody

DTNA, CT (DTNA, DRP3, Dystrobrevin alpha, Alpha-dystrobrevin, Dystrophin-related protein 3) (FITC)

Cat. Num. AAA6293634

• Gene Names: DTNA; DTN; DRP3; DTN-A; LVNC1; D18S892E
• Reactivity: Mouse
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: DTNA; Polyclonal Antibody; CT (DTNA; DRP3; Dystrobrevin alpha; Alpha-dystrobrevin; Dystrophin-related protein 3) (FITC); Dystrophin-related protein 3; anti-DTNA antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Sequence Length: 567

• Applicable Applications for anti-DTNA antibody: Immunofluorescence (IF), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IF: 1:10-50; FLISA: 1:1,000; IHC: 1:10-50; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: DTNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 691-721 amino acids from the C-terminal region of human DTNA.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(DTNA Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the DTNA antibody detected the DTNA protein (arrow).)

Immunohistochemistry (IHC)

(DTNA Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DTNA Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Immunofluorescence (IF)

(Confocal immunofluorescent analysis of DTNA Antibody (C-term) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)

Related Product Information for anti-DTNA antibody

The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha-and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Product Categories/Family for anti-DTNA antibody

Antibodies; Proteins

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Bohm, S.V., et al. BMC Biol. 7, 85 (2009): Nakamori, M., et al. Neurology 70(9):677-685(2008). Lamesch, P., et al. Genomics 89(3):307-315(2007). Lim, J., et al. Cell 125(4):801-814(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 42718001
• NCBI GeneID: 1837
• NCBI Accession #: NP_116760.2; NP_001383.2
• NCBI GenBank Nucleotide #: NP_116760.2
• UniProt Accession #: Q9Y4J8
• NCBI Official Full Name: dystrobrevin alpha isoform 4
• NCBI Official Synonym Full Names: dystrobrevin alpha
• NCBI Official Symbol: DTNA
• NCBI Official Synonym Symbols: DTN; DRP3; DTN-A; LVNC1; D18S892E
• NCBI Protein Information: dystrobrevin alpha
• UniProt Protein Name: Dystrobrevin alpha
• Protein Family: Dystrobrevin
• UniProt Gene Name: DTNA
• UniProt Synonym Gene Names: DRP3; DTN-A

NCBI Description

The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.