Rabbit DREG / GPR126 Polyclonal Antibody | anti-DREG antibody

Rabbit Polyclonal to Human DREG / GPR126

Cat. Num. AAA243913

• Gene Names: GPR126; APG1; DREG; VIGR; PS1TP2
• Reactivity: Bat, Gibbon, Bovine, Chicken, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rabbit, Rat
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: DREG / GPR126; Polyclonal Antibody; Rabbit Polyclonal to Human DREG / GPR126; Anti-DREG / GPR126 Antibody (N-Terminus) IHC-plus; GPR126; APG1; G-protein coupled receptor 126; PS1TP2; VIGR; DREG; G protein-coupled receptor 126; Human DREG; anti-DREG antibody

• Host: Rabbit
• Reactivity: Bat, Gibbon, Bovine, Chicken, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rabbit, Rat
• Clonality: Polyclonal
• Specificity: Human GPR126. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR64 (72%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1221

• Applicable Applications for anti-DREG antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (10 ug/ml); Usage: Proteinase K treatment is required for antigen retrieval.
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from N-terminal extracellular domain of human GPR126.
• Immunogen Type: Synthetic peptide
• Immunogen: DREG / GPR126 antibody was raised against synthetic 18 amino acid peptide from N-terminal extracellular domain of human GPR126. Percent identity with other species by BLAST analysis: Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Bat, Horse, Rabbit, Opossum, Turkey, Chicken (100%); Human, Lizard (94%); Xenopus, Stickleback, Pufferfish, Zebrafish (83%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-GPR126 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPR126 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-DREG antibody

GPR126 is an Orphan-B GPCR with an unknown ligand. This may be a very large gene with alternatively spliced transcripts.

Product Categories/Family for anti-DREG antibody

Family: GPCR; Subfamily: Orphan-B

NCBI and Uniprot Product Information

• NCBI GI #: 74048357
• NCBI GeneID: 57211
• NCBI Accession #: NP_065188.4
• NCBI GenBank Nucleotide #: NM_020455.5
• UniProt Accession #: Q86SQ4; Q5TGN7; Q6DHZ4; Q6F3F5; Q6F3F6; Q6F3F7; Q6F3F8; Q6MZU7; Q8IXA4; Q8NC14; Q96JW0
• Molecular Weight: 136,878 Da
• NCBI Official Full Name: G-protein coupled receptor 126 isoform alpha 1
• NCBI Official Synonym Full Names: G protein-coupled receptor 126
• NCBI Official Symbol: GPR126
• NCBI Official Synonym Symbols: APG1; DREG; VIGR; PS1TP2
• NCBI Protein Information: G-protein coupled receptor 126; HBV PreS1-transactivated protein 2; vascular inducible G protein-coupled receptor; vascular-inducible G protein-coupled receptor; developmentally regulated G-protein-coupled receptor
• UniProt Protein Name: G-protein coupled receptor 126
• UniProt Gene Name: GPR126
• UniProt Synonym Gene Names: DREG; VIGR
• UniProt Entry Name: GP126_HUMAN

NCBI Description

This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Description

GPR126: Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2

Chromosomal Location of Human Ortholog: 6q24.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway