Rabbit anti-Human, Rat DPYSL5 Polyclonal Antibody | anti-DPYSL5 antibody

DPYSL5 (Dihydropyrimidinase-related Protein 5, DRP-5, CRMP3-associated Molecule, CRAM, Collapsin Response Mediator Protein 5, CRMP-5, UNC33-like Phosphoprotein 6, ULIP-6, CRMP5, ULIP6) (HRP)

Cat. Num. AAA6376561

• Gene Names: DPYSL5; CRAM; CRMP5; Ulip6; CRMP-5
• Reactivity: Human, Rat
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: DPYSL5; Polyclonal Antibody; DPYSL5 (Dihydropyrimidinase-related Protein 5; DRP-5; CRMP3-associated Molecule; CRAM; Collapsin Response Mediator Protein 5; CRMP-5; UNC33-like Phosphoprotein 6; ULIP-6; CRMP5; ULIP6) (HRP); anti-DPYSL5 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human DPYSL5. Species Crossreactivity: rat.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-DPYSL5 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human DPYSL5, aa1-564 (NP_064519.2).
• Immunogen Sequence: MLANSASVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCCDYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGAIARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGGKMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREKTLKVRGVDRTPYLGDVAVVVHPGKKEMGTPLADTPTRPVTRHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSSGIW
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(DPYSL5 rabbit polyclonal antibody. Western Blot analysis of DPYSL5 expression in rat brain.)

Western Blot (WB)

(Western Blot analysis of DPYSL5 expression in transfected 293T cell line by DPYSL5 polyclonal antibody. Lane 1: DPYSL5 transfected lysate (61.4kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-DPYSL5 antibody

The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus.

Product Categories/Family for anti-DPYSL5 antibody

Antibodies; Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 19923821
• NCBI GeneID: 56896
• NCBI Accession #: NP_064519.2
• NCBI GenBank Nucleotide #: NM_020134
• UniProt Accession #: Q9BPU6; Q8TCL6; Q9NQC4; Q9NRY9
• Molecular Weight: 61,421 Da
• NCBI Official Full Name: dihydropyrimidinase-related protein 5
• NCBI Official Synonym Full Names: dihydropyrimidinase like 5
• NCBI Official Symbol: DPYSL5
• NCBI Official Synonym Symbols: CRAM; CRMP5; Ulip6; CRMP-5
• NCBI Protein Information: dihydropyrimidinase-related protein 5
• UniProt Protein Name: Dihydropyrimidinase-related protein 5
• Protein Family: Dihydropyrimidinase-related protein
• UniProt Gene Name: DPYSL5
• UniProt Synonym Gene Names: CRMP5; ULIP6; DRP-5; CRAM; CRMP-5; ULIP-6
• UniProt Entry Name: DPYL5_HUMAN

NCBI Description

This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

Uniprot Description

CRMP-5: May have a function in neuronal differentiation and/or axon growth. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: cell soma; dendrite; cytosol

Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Biological Process: nervous system development; axon guidance; signal transduction; pyrimidine base catabolic process