Western Blot (WB)
(DPEP1 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the DPEP1 antibody detected the DPEP1 protein (arrow).)
Rabbit anti-Human DPEP1 Polyclonal Antibody | anti-DPEP1 antibody
DPEP1 Antibody (N-term)
Western Blot (WB)
(DPEP1 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the DPEP1 antibody detected the DPEP1 protein (arrow).)
Western Blot (WB)
(DPEP1 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the DPEP1 antibody detected the DPEP1 protein (arrow).)
hydrolyzes a variety of dipeptides and is implicated in renal
metabolism of glutathione and its conjugates, e.g., leukotriene D4
(Kozak and Tate, 1982 [PubMed 6122685]). DPEP1 is responsible for
hydrolysis of the beta-lactam ring of antibiotics, such as penem
and carbapenem (Campbell et al., 1984 [PubMed 6334084]). Earlier,
beta-lactamase enzymes were thought to occur only in bacteria,
where their probable function was in protecting the organisms
against the action of beta-lactam antibiotics. These antibiotics
exhibit selective toxicity against bacteria but virtual inertness
against many eukaryotic cells (Adachi et al., 1990 [PubMed
2303490]).
Pare, G., et al. Circ Cardiovasc Genet 2(2):142-150(2009)
Nitanai, Y., et al. J. Mol. Biol. 321(2):177-184(2002)
Kera, Y., et al. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 123(1):53-58(1999)
Satoh, S., et al. Biotechnol. Prog. 10(2):134-140(1994)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Description
DPEP1: Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity. Belongs to the peptidase M19 family.
Protein type: Protease; EC 3.4.13.19; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component: extracellular space; microvillus membrane; apical part of cell; apical plasma membrane; plasma membrane; cell junction; nucleus
Molecular Function: protein binding; metalloexopeptidase activity; zinc ion binding; dipeptidyl-peptidase activity; caspase inhibitor activity
Biological Process: glutathione metabolic process; xenobiotic metabolic process; arachidonic acid metabolic process; leukotriene metabolic process; homocysteine metabolic process; negative regulation of caspase activity; proteolysis; negative regulation of cell migration; antibiotic metabolic process; negative regulation of apoptosis
Research Articles on DPEP1
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Product Notes
The DPEP1 dpep1 (Catalog #AAA9205045) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-30. The DPEP1 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DPEP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the DPEP1 dpep1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DPEP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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