Western Blot (WB)
(DPAGT1 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the DPAGT1 antibody detected the DPAGT1 protein (arrow).)
Rabbit anti-Human, Mouse DPAGT1 Polyclonal Antibody | anti-DPAGT1 antibody
DPAGT1, NT (DPAGT1, DPAGT2, UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, GlcNAc-1-P transferase, N-acetylglucosamine-1-phosphate transferase) (Azide free) (HRP)
ELISA: 1:1,000
Applications are based on unconjugated antibody.
Western Blot (WB)
(DPAGT1 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the DPAGT1 antibody detected the DPAGT1 protein (arrow).)
Western Blot (WB)
(DPAGT1 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the DPAGT1 antibody detected the DPAGT1 protein (arrow).)
Western Blot (WB)
(DPAGT1 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the DPAGT1 antibody detected the DPAGT1 protein (arrow).)
Western Blot (WB)
(DPAGT1 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the DPAGT1 antibody detected the DPAGT1 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]
Uniprot Description
DPAGT1: Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides. Defects in DPAGT1 are the cause of congenital disorder of glycosylation type 1J (CDG1J). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the glycosyltransferase 4 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; EC 2.7.8.15; Membrane protein, integral; Membrane protein, multi-pass; Glycan Metabolism - N-glycan biosynthesis; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; membrane; integral to membrane; integral to endoplasmic reticulum membrane
Molecular Function: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity; transferase activity, transferring glycosyl groups; phospho-N-acetylmuramoyl-pentapeptide-transferase activity
Biological Process: polysaccharide biosynthetic process; UDP-N-acetylglucosamine metabolic process; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; protein amino acid N-linked glycosylation; protein amino acid N-linked glycosylation via asparagine; dolichol biosynthetic process; post-translational protein modification; protein oligomerization
Disease: Congenital Disorder Of Glycosylation, Type Ij; Myasthenic Syndrome, Congenital, With Tubular Aggregates 2
Research Articles on DPAGT1
Similar Products
Product Notes
The DPAGT1 dpagt1 (Catalog #AAA6293261) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DPAGT1, NT (DPAGT1, DPAGT2, UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, GlcNAc-1-P transferase, N-acetylglucosamine-1-phosphate transferase) (Azide free) (HRP) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's DPAGT1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:100-500 ELISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the DPAGT1 dpagt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DPAGT1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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